Scientists have uncovered a new enzyme that works to block the adverse effects of sugar on the body. Present in all mammals, the enzyme plays the role of disposing of the unwanted byproducts of heightened glucose levels. In discovering this key step in the metabolism of sugar, the scientists say they have uncovered a new therapeutic target for conditions like type 2 diabetes and obesity, and are now working to develop drugs that boosts its activity.
Enlisting the body's naturally produced T cells to fight off cancer is an immunotherapy technique that has shown early promise in clinical trials. But one limitation is that these cells generally lack the firepower to do the job on their own, meaning they need to be modified and reintroduced to the bloodstream to have a real impact. Researchers may now have discovered a more efficient way forward, with the development of a T cell-loaded biogel that can be injected directly into the tumor for a more targeted, less laborious approach to immunotherapy.