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Salk Institute

Medical

Creation of insulin-releasing cells in a dish offers hope of diabetes therapy

A molecular switch could hold the key to a personalized cell replacement therapy for diabetes. Both Type 1 and Type 2 diabetes are characterized by an inability to produce (or process) insulin, which is required to regulate blood sugar levels. This has been linked to malfunctioning or failing beta cells in the pancreas, but so far scientists have struggled to produce effective replacement cells in the lab. Now a team at Salk Institute believes the problem has been solved.Read More

Biology

Scientists discover a "mini-brain" in spinal cord that helps keep us balanced

Keeping ourselves upright is something most of us shouldn't need to think a whole lot about, given we've been doing it almost our entire lives. But when it comes to dealing with more precarious terrain, like walking on ice or some sort of tight rope, you might think some pretty significant concentration is required. But researchers have found that even in our moments of great instability, our subconsciousness is largely responsible for keeping us from landing on our backsides. This is due to what scientists are describing as a mini-brain, a newly mapped bunch of neurons in the spinal cord which processes sensory information and could lead to new treatment for ailing motor skills and balance.Read More

Health & Wellbeing

Diet pill tricks body into burning fat, by making it think you've eaten

When we eat a meal, our body detects that we've consumed calories and responds by burning fat in order to make room for them. The catch for the weight-conscious is that if we don't burn off those newly-arrived calories, they just end up being stored as more fat. For people with metabolic disorders or other conditions, exercise just isn't enough to keep that from happening. Soon, however, a newly-developed drug could help. It triggers the body's "burning fat to make space for calories" response, even when the patient hasn't eaten anything. Read More

Medical

Research suggests there may be an off switch for drug resistance in cancer cells

In cancer treatments such as chemotherapy, hundreds of thousands of cancerous cells are killed off. But if even one of these cells has a unique mutation, it can survive the treatment and start to multiply, giving rise to a set of more drug-resistant cells. Researchers at the Salk Institute in California have now gained new insights into what exactly is causing these variations in the cells, suggesting there may in fact be a way of switching off the mechanism and improving treatment effectiveness. Read More

Medical

Single injection reverses type 2 diabetes symptoms in mice without side effects

There are numerous research efforts underway to develop new treatments and improve the lives of people suffering type 2 diabetes, whose ranks have increased dramatically in recent decades due in large part to the so-called obesity epidemic. A new generation of safer and more effective diabetes drugs could be in the offing with researchers at the Salk Institute discovering that when mice with diet-induced diabetes were given a single injection of a protein, their blood sugar levels were restored to a healthy range for more than two days.Read More

Health & Wellbeing

Compound in fruits and vegetables prevents symptoms of Alzheimer's disease in mice

Alzheimer's disease represents the most common form of dementia, with the early stages of the disease generally characterized with short term memory loss and learning difficulties that increase in severity as the patient progresses in age. Scientists at the Salk Institute for Biological Studies, California, have discovered that with regular treatments of the antioxidant fisetin, they were able to prevent memory loss in mice with genetic mutations linked to Alzheimer's.Read More

Health & Wellbeing

New drug could be the first to prevent the progression of Alzheimer's disease

Anyone who has watched as Alzheimer’s disease robs a friend or family member of their memories and faculties before ultimately claiming their life knows just what a truly horrible disease it is. According to the World Health Organization, it is the fourth leading cause of death in high-income countries and, due to an aging worldwide population, it is predicted to affect one in 85 people worldwide by 2050 – unless a treatment can be found. Scientists at the Salk Institute for Biological Studies have high hopes for a new drug they have developed that has improved memory and prevented brain damage in mice and is a promising candidate for the first drug capable of halting the progression of Alzheimer’s in humans.Read More

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