Highlights from the 2014 LA Auto Show

Salk Institute

Salk Institute researchers studied thousands of molecules to shed new light on the develop...

In cancer treatments such as chemotherapy, hundreds of thousands of cancerous cells are killed off. But if even one of these cells has a unique mutation, it can survive the treatment and start to multiply, giving rise to a set of more drug-resistant cells. Researchers at the Salk Institute in California have now gained new insights into what exactly is causing these variations in the cells, suggesting there may in fact be a way of switching off the mechanism and improving treatment effectiveness.  Read More

The discovery of an on/off switch for telomerase could provide a way to get human cells to...

Researchers at the Salk Institute have discovered an on/off switch for telomerase, an enzyme that rebuilds a cellular timekeeper known as a telomere. The scientists believe that the discovery could provide a way to get human cells to divide indefinitely without degenerating, thereby regenerating healthy organs even in old age.  Read More

Researchers at the Salk Institute have found that the FGF1 protein shows promise for the d...

There are numerous research efforts underway to develop new treatments and improve the lives of people suffering type 2 diabetes, whose ranks have increased dramatically in recent decades due in large part to the so-called obesity epidemic. A new generation of safer and more effective diabetes drugs could be in the offing with researchers at the Salk Institute discovering that when mice with diet-induced diabetes were given a single injection of a protein, their blood sugar levels were restored to a healthy range for more than two days.  Read More

A compound commonly found in fruit and vegetables, including apples, grapes and strawberri...

Alzheimer's disease represents the most common form of dementia, with the early stages of the disease generally characterized with short term memory loss and learning difficulties that increase in severity as the patient progresses in age. Scientists at the Salk Institute for Biological Studies, California, have discovered that with regular treatments of the antioxidant fisetin, they were able to prevent memory loss in mice with genetic mutations linked to Alzheimer's.  Read More

A new compound, J147, could be the first drug capable of halting the progression of Alzhei...

Anyone who has watched as Alzheimer’s disease robs a friend or family member of their memories and faculties before ultimately claiming their life knows just what a truly horrible disease it is. According to the World Health Organization, it is the fourth leading cause of death in high-income countries and, due to an aging worldwide population, it is predicted to affect one in 85 people worldwide by 2050 – unless a treatment can be found. Scientists at the Salk Institute for Biological Studies have high hopes for a new drug they have developed that has improved memory and prevented brain damage in mice and is a promising candidate for the first drug capable of halting the progression of Alzheimer’s in humans.  Read More

Pumped-up muscle tissue (in blue) in a high performing 'mighty mouse'

He can't fly just yet, but a team of scientists have made a big step towards creating a real-life Mighty Mouse. Researchers at the Salk Institute for Biological Studies, along with two Swiss institutions, Ecole Polytechnique Federale de Lausanne (EPFL) and the University of Lausanne, created a batch of super-strong mice and worms by tweaking a gene that normally inhibits muscle growth.  Read More

The even distribution of different cell types seen in the intestinal tissues of young frui...

Caloric restriction has been shown to slow the signs of aging and delay the development of age-related diseases in a wide range of animals. However, scientists have been unable to explain just why limiting daily food intake has such a beneficial effect on health and the biological mechanisms that underlie the phenomenon. Researchers in Sweden recently claimed to have unlocked a piece of the puzzle by identifying one of the enzymes that appears to play a major role in the process and now another group in the U.S. has provided another clue by tweaking a gene in fruit flies and extending their lifespan by as much as 50 percent.  Read More

The mice before and after injections with astressin-B

While conducting research into brain-gut interactions, a team led by researchers from UCLA and the Veterans Administration may have inadvertently stumbled across a new treatment for hair loss. During an investigation into the affect of stress on gastrointestinal function, the researchers believe they may have found a chemical compound that induces hair growth by blocking a stress-related hormone associated with hair loss.  Read More

A human retina, which was the focus of the study

A better understanding of color vision has been gained in a feat of interdisciplinary and inter-institutional science. Researchers from neuroscience, nanoengineering, physics and electronics departments at universities on opposite sides of the world have come together to build a sensor that detects activity in the neural circuitry of the eye with a level of accuracy never before seen.  Read More

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