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Cartilage

A demonstration of the ultrasonic tweezers (Photo: University of Southampton)

Although it's now possible to create lab-grown cartilage, there's still at least one big challenge in doing so – cartilage grown in a flat Petri dish may not be optimally-shaped for replacing the body's own natural cartilage parts. Scientists from a consortium of UK universities, however, are developing a possible solution. They're using "ultrasonic tweezers" to grow cartilage in mid-air.  Read More

Knee cartilage anatomy: the source of many problems for osteoarthritis sufferers (Image: G...

3D bioprinting experts at the University of Pittsburgh’s School of Medicine are examining techniques that print stem cells into robust scaffolding structures directly at the site of cartilage damage, in an effort to repair damaged cartilage and prevent osteoarthritis.  Read More

The engineered cartilage was grown from the patient's own cells and could provide a less-i...

Researchers from Switzerland's University of Basel have performed the first successful nose reconstruction surgery using engineered cartilage grown in the laboratory. The cartilage was spawned form the patient's own cells in an approach that could circumvent the need for more invasive surgeries.  Read More

Damaged or deformed ears could be rebuilt using the patient's own fat (Photo: Shutterstock...

Researchers at London's Great Ormond Street Hospital aim to grow a human ear via stem cells taken from a patient's fat tissue. Relatively little attention has been given to the reconstruction of damaged cartilage around the cranial area, however the new method is hoped to modernize this area of reconstructive surgery.  Read More

The BioPen lets surgeons 'draw' live cells and growth factors directly onto the site of an...

Devices like the 3Doodler and SwissPen literally put 3D printing technology in the hands of consumers, but a new BioPen developed at the University of Wollongong in Australia is targeted at more skilled hands. The handheld device is designed to let surgeons "draw" live cells and growth factors directly onto the site of an injury to help accelerate the regeneration of functional bone and cartilage.  Read More

Researcher Lawrence Bonassar holds a fabricated ear created with a 3D printer (Photo: Lind...

When a child is born with the congenital deformity known as microtia, they have an underdeveloped external ear – also known as the pinna. Even though their inner ear may be normal, the lack of the external structure can affect their hearing, plus it looks unusual. Normally, a replacement pinna is made from a foam-like material (or sometimes even cartilage from the rib cage) and implanted under the skin, although these don’t always look particularly natural. Now, scientists from Cornell University have developed a more realistic pinna grown from biological material, using a 3D printer.  Read More

The experimental 3D printer, which combines electrospinning and ink jet printing technolog...

Generally speaking, injured cartilage doesn’t heal well ... if at all. In recent years, however, scientists have successfully regrown cartilage at injury sites, using things like hydrogel, microspheres and collagen-based nano-scaffolding. Now, a team of scientists led by Prof. James Yu of North Carolina's Wake Forest Institute for Regenerative Medicine have developed something else – a 3D printer that creates implantable cartilage.  Read More

The hydrogel in its relaxed state (left), and stretched by a factor of 21

Scientists at Harvard University have created a hydrogel that’s tough, biocompatible, self-healing, and can be repeatedly stretched to 21 times its regular length without breaking – all of which are qualities that could make it an ideal replacement for damaged cartilage in humans. Being a hydrogel, it’s composed mostly of water, although it also contains calcium ions, and a mix of two common polymers. While each of those polymers are fairly weak on their own, the results are truly impressive when they’re combined.  Read More

A cross-section of engineered cartilage tissue, which initially incorporated fast-degradin...

Injuries involving torn or degraded joint cartilage can be very debilitating, especially since that cartilage is incapable of healing itself, past a certain point. It's not surprising, therefore, that numerous scientists have been working on ways of either growing replacement cartilage outside of the body, or helping the body to regrow it internally. Just a few of the efforts have included things like stem cell-seeded bandages, bioactive gel, tissue scaffolds, and nanoscale stem cell-carrying balls. Now, researchers from Cleveland's Case Western Reserve University have announced something else that shows promise - sheets of mesenchymal (bone and cartilage-forming) stem cells, permeated with tiny beads filled with the growth factor beta-1.  Read More

A new type of stem-cell-seeded bandage, designed to heal torn meniscal cartilage such as  ...

Every year, approximately 1.7 million people in the U.S. and Europe tear a meniscus – children and athletes are especially prone to such injuries. But first, just what is a meniscus? It’s one of two pieces of cartilage located inside each knee, that provide a cushion between the tibia and the femur. While smaller tears can heal on their own, larger tears often require a partial or complete removal of the meniscus. Within several years, this can result in the early onset of osteoarthritis. Recently, a new type of stem cell-seeded bandage, developed at the University of Bristol, has been approved for a clinical trial on meniscal tears. It may greatly reduce the need for menisectomies.  Read More

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