Top 100: The most desirable cars of all time

Creation of liver cells from skin cells gives hope in fight against liver disease

By

August 29, 2010

A human liver (Image: Department of Histology, Jagiellonian University Medical College)

A human liver (Image: Department of Histology, Jagiellonian University Medical College)

Researching liver disorders is extremely difficult because liver cells (hepatocytes) cannot be grown in the laboratory. However, researchers at the University of Cambridge have now managed to create diseased liver cells from a small sample of human skin. The research shows that stem cells can be used to model a diverse range of inherited disorders and paves the way for new liver disease research and possible cell-based therapy.

Liver disease on the rise

In the UK, liver disease is the fifth largest cause of death after cardiovascular, cancer, stroke, and respiratory diseases. Over the past 30 years mortality from liver disease in young and middle-aged people has increased over six times, with the number of individuals dying from the disease increasing at a rate of 8-10 percent every year.

By 2012, the UK is expected to have the highest liver disease death rates in Europe and, without action to tackle the disease, it could overtake stroke and coronary heart disease as the leading cause of death within the next 10-20 years. In the United States, it accounts for approximately 25,000 deaths a year.

Cell-based therapy?

By replicating the liver cells, researchers can not only investigate exactly what is happening in a diseased cell, they can also test the effectiveness of new therapies to treat these conditions. It is hoped that their discovery will lead to tailored treatments for specific individuals and eventually cell-based therapy – when cells from patients with genetic diseases are 'cured' and transplanted back. Additionally, as the process could be used to model cells from other parts of the body, their findings could have implications for conditions affecting other organs.

For their research, the scientists took skin biopsies from seven patients who suffered from a variety of inherited liver diseases and three healthy individuals (the control group). They then reprogrammed cells from the skin samples back into stem cells. These stem cells were then used to generate liver cells which mimicked a broad range of liver diseases – the first time patient-specific liver diseases have been modeled using stem cells – and to create 'healthy' liver cells from the control group. Importantly, the three diseases the scientists modeled covered a diverse range of pathological mechanisms, thereby demonstrating the potential application of their research on a wide variety of disorders.

Dr Tamir Rashid of the Laboratory for Regenerative Medicine, University of Cambridge, lead author of the paper detailing the team’s findings, said: "We know that given the shortage of donor liver organs alternative strategies must urgently be sought. Our study improves the possibility that such alternatives will be found – either using new drugs or a cell-based therapeutic approach."

The University of Cambridge researchers' findings were published in The Journal of Clinical Investigation.

About the Author
Darren Quick Darren's love of technology started in primary school with a Nintendo Game & Watch Donkey Kong (still functioning) and a Commodore VIC 20 computer (not still functioning). In high school he upgraded to a 286 PC, and he's been following Moore's law ever since. This love of technology continued through a number of university courses and crappy jobs until 2008, when his interests found a home at Gizmag.   All articles by Darren Quick
2 Comments

"I'll Drink to that"..... Well someone had to say it.

Michael Mantion
30th August, 2010 @ 04:57 pm PDT

Damn, Michael beat me for this post, regards, bill

Bill Bennett
30th August, 2010 @ 06:45 pm PDT
Post a Comment

Login with your gizmag account:

Or Login with Facebook:


Related Articles
Looking for something? Search our 29,901 articles
Recent popular articles in Science
Product Comparisons