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Remote-controlled spermbots could be used to fertilize eggs

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January 14, 2014

Spermbots created at IFW Dresden approach an egg, and the microtube falls away (Image: IFW...

Spermbots created at IFW Dresden approach an egg, and the microtube falls away (Image: IFW Dresden, Germany)

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Hijacking sperm cells to create little robots might seem far out, but that's exactly what researchers from the Dresden Institute for Integrative Nanosciences have done. Their "spermbots" consist of live sperm cells in little tubes, that can be magnetically controlled to move in a desired direction until they reach their destination and do their job – they're currently robust enough to even guide a specific sperm cell to an egg cell. The scientists hope that further development will allow the technology to offer a viable alternative to parents trying to have a child through in-vitro fertilization. When perfected, the spermbots could also be used as a safe means for drug delivery and gene manipulation.

One of the major challenges in creating micro robots that can potentially travel within the human body is the issue of a safe fuel source. Nanobots with engines efficient enough to propel themselves through bodily fluids need to carry fuel that's often toxic to the human body, and sometimes these machines can pass through into the cells and affect their functioning. To overcome these problems, the Dresden team began looking at safer alternatives to artificial nano engines.

"We thought of using a powerful biological motor to do the job instead and we came up with the flagella of a sperm cell, which is physiologically less problematic," Professor Oliver G. Schmidt, the Institute's Director, tells Gizmag. "The idea came to us five years ago when I noticed that sperm cells are of similar size to microtubes we can fabricate."

To create biorobots out of sperm cells, the researchers began working with bovine (bull) sperm cells – which are similar in size to human sperm cells. The first step was to create thin conical magnetic tubes capable of trapping sperm cells out of a titanium and iron film. The microtubes are rolled up in a way that makes one end larger than the other, with a diameter that's slightly larger than that of a bull sperm head.

When live sperm cells are added to a solution containing these microtubes in a petri dish, the sperm swim about and enter the tubes randomly. Once inside, they are locked down mechanically and begin pushing the tube forward as they move about. Magnetic material present in the tubes makes it possible to get remote-controlled sperm.

Scanning Electron Microscopic image of a rolled-up microtube, with the bull sperm cell at ...

"We used a magnetic field to guide the direction of the so-called 'spermbots' and changed the temperature to control their speeds," Schmidt explains. "All this was done in-vitro, i.e. outside the body."

Once the spermbot reaches the desired location, it could be manipulated magnetically to release the sperm. While the researchers are still working on the issue, they state that it should be possible to set the sperms free by altering the temperature to unroll the tubes, just before they reach the egg. The microtubes could be removed from the body by applying the magnetic field appropriately, with little if any risk.

"Compared to magnetic nanoparticles, magnetic microtubes are not as hazardous, because they do not enter the cells," Veronika Magdanz, a researcher at the Institute tells us. "They are larger than the cell itself."

Sperm cells are ideal candidates to transform into biobots since they are easily available, harmless and efficient at swimming through bodily fluids. With a chip about 22 x 22 mm (0.8 in x 0.8 in) in size, the researchers have been able to produce around 200,000 well-defined microtubes. In initial tests, the team worked with thawed-out bull sperm cells that remained viable for a few hours.

It's possible to make hundreds of spermbots with microtubes obtained from a single chip, each capable of traveling up to 100 micrometers per second. That's about two body lengths of the sperm-driven tube per second – comparable to a 1.80 m (6 ft) tall human swimming the 50 m (160 ft) free-style in 14 seconds.

The team plans to try assisted fertilization with animals before starting experiments and clinical trials with human sperm. Since it's possible to control the path of these spermbots to the tune of a few micrometers, the spermbots could ultimately also be utilized to ferry drugs and payloads anywhere within the body.

A paper describing the technology, entitled "3D Magnetic Control Of Microjets" is due to be published soon in the journal Applied Physics Letters.

Source: IFW Dresden

About the Author
Lakshmi Sandhana When Lakshmi first encountered pig's wings in a petri dish, she realized that writing about scientists and imagineers was the perfect way to live in an expanding mind bubble. Articles for Wired, BBC Online, New Scientist, The Economist and Fast Company soon followed. She's currently pursuing her dream of traveling from country to country to not only ferret out cool stories but also indulge outrageously in local street foods. When not working, you'll find her either buried nose deep in a fantasy novel or trying her hand at improvisational comedy.   All articles by Lakshmi Sandhana
6 Comments

It's interesting to see how scientists are able to lock-up individual sperm cells inside containers, but i don't see actually how these "spermbots" will be viable alternative to IVF. Guided movement? Where? Inside woman's fallopian tubes? With magnetic field? It's of course nice to see that scientists are enable to utilize sperms capacity to move but it doesn't help in any way by fertilization compared to the same moving sperm without manipulation or "botifying". And there is rarely problem in moving sperm to oocyte to fertilize -problems lay in: movement through oocytes cumulus cells and zona pellucida > entering oocyte > unpacking sperm's genetical material inside oocyte > competence of the sperm DNA (and oocyte DNA) etc. If a couple can't become pregnant in natural way then this scientific breakthrough doesn't help them in any particular way... as alternative to in vitro fertilization...

Another point is removal of these capsules - by magnetic field? from inside fallopian tubes? I'm kinda skeptic at the moment...

Andre Taimalu
15th January, 2014 @ 03:18 am PST

@ Andre Taimalu: Thanks a lot for your comment! You are very right in your statement. We realize the challenge of this application in vivo and only future experiments will reveal its real potential. However, we think it is important to reach high. We often say "If it was easy, it would be already done".

V.Magdanz, IFW Dresden

V.Magdanz
15th January, 2014 @ 06:12 am PST

Another Frankenstein idea: piggybacking sperm with toxic magnetic oxides that may damage the ovum leading to genetic abnormalities or death of the ovum, hopefully also seen in animal studies that may not be meaningful in light of thalidomide.

rutnerh
15th January, 2014 @ 08:45 am PST

With projected world populations how does this 'research' even get funding?

Ozuzi
15th January, 2014 @ 05:33 pm PST

Oh that's just great. I'm not getting enough sex as it is.

noteugene
15th January, 2014 @ 07:10 pm PST

@Andre Taimalu and @ V.Magdanz

I am not contesting if this technology would be viable or not since I don't have much knowledge on 3d magnetic control. I think though that if the technology is proven to be effective motile DNA healthy sperm cells that could bind with the zona pellucida could be picked by high imaging and hyaluronan techniques and since spermatozoa would be “guided”, only a few could be used instead of hundreds of thousands. My main concerns would be in relation to fallopian tubes. Considering that IUI would be applied bypassing obstacles such as hostile vaginal and cervical mucus you would still be facing problems on the fallopian tubes that account for high rates of so common “unexplained infertility”. Even tubes that appear healthy and patent on HSG can have the following problems:

-Small amounts and/or unhealthy amounts of ciliated cells that are fundamental for transportation of oocyte (and embrio after conception).

- Peg cells are producing mucus that is too poor on essential nutrients for sperm and egg survival or mucus that is too viscous for gametes to be transported inside tubes.

- Non scarred tubes apparently patent on HSG can still become partially blocked by “plugs” of concentrations of very viscous mucus and organic debris from time to time.

Considering these aspects I think that this technology, at this stage at least, could be applied for Fallopian tube diagnostics and possibly even treatment since guided sperm cells could be less intrusive than a catheter. The benefit would be that more cases of unexplained infertility could be explained and properly addressed with right treatment and less people would have to undergo ivf which is full of side effects and very costly. As a last comment I think that this is a great work that could open a whole range of possibilities.

John Fuentes
15th January, 2014 @ 07:19 pm PST
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