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Researchers stumble on potential new treatment for hair loss

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February 17, 2011

The mice before and after injections with astressin-B

The mice before and after injections with astressin-B

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While conducting research into brain-gut interactions, a team led by researchers from UCLA and the Veterans Administration may have inadvertently stumbled across a new treatment for hair loss. During an investigation into the affect of stress on gastrointestinal function, the researchers believe they may have found a chemical compound that induces hair growth by blocking a stress-related hormone associated with hair loss.

It's long been recognized that stress plays a role in hair loss and, although there have been numerous hair-restoration remedies emerge over the years, even legitimate medications such as minoxidil have only shown limited effectiveness. The UCLA-led team says their findings show that the chemical compound they have uncovered could provide long-term hair regrowth from a short-duration treatment.

Instead of looking for mice burdened with debt or in the process of moving house, for their research the researchers had been using mice that were genetically altered to overproduce a stress hormone called corticotrophin-releasing factor, or CRF. As these mice age, they lose hair and eventually become bald on their backs, making them visually distinct from their unaltered counterparts.

The UCLA and VA researchers then injected a peptide called astressin-B, which has the ability to block the action of CRF, into the bald mice to observe how its CRF-blocking ability affected gastrointestinal tract function. When the initial single injection had no effect the investigators continued the injections over five days to give the peptide a better chance of blocking the CRF receptors. They measured the effects of this regimen on the stress-induced response in the colons of the mice and placed the mice back in the cages with their hairy counterparts.

The mice before and after injections with astressin-B

Three months later the researchers returned to the mice to conduct further gastrointestinal studies and found they couldn't distinguish them from their unaltered brethren as their previously bald backs were now covered in hair.

"When we analyzed the identification number of the mice that had grown hair we found that, indeed, the astressin-B peptide was responsible for the remarkable hair growth in the bald mice," said Million Mulugeta, an adjunct professor of medicine in the division of digestive diseases at the David Geffen School of Medicine at UCLA and a corresponding author of the research. "Subsequent studies confirmed this unequivocally," he added.

Particularly noteworthy was the fact that just one injection a day for five consecutive days was enough to maintain the effects for up to four months.

"This is a comparatively long time, considering that mice's life span is less than two years," Mulugeta said.

Whether the same effect happens in humans remains to be seen, but the researchers say the fact that the bald mice also showed mild hair growth when treated with minoxidil alone, as is the case in humans, suggests that astressin-B could also produce hair regrowth in humans. In fact, it is known that the stress-hormone CRF, its receptors and other peptides that modulate these receptors are found in human skin.

UCLA and the Salk Institute have applied for a patent on the use of the astressin-B peptide for hair growth.

About the Author
Darren Quick Darren's love of technology started in primary school with a Nintendo Game & Watch Donkey Kong (still functioning) and a Commodore VIC 20 computer (not still functioning). In high school he upgraded to a 286 PC, and he's been following Moore's law ever since. This love of technology continued through a number of university courses and crappy jobs until 2008, when his interests found a home at Gizmag.   All articles by Darren Quick
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11 Comments

I volunteer for trials!

Facebook User
18th February, 2011 @ 09:12 am PST

me too!

Bill Bennett
18th February, 2011 @ 07:24 pm PST

Could you please show me where I may buy a BOATLOAD OF ASTRESSIN-B !

GeorgeAbitbol
19th February, 2011 @ 02:23 am PST

Im A-stressin for Astressin-b

peptide junkie
25th February, 2011 @ 05:30 pm PST

Did the stress free mice live longer?

voluntaryist
1st March, 2011 @ 08:55 pm PST

Before all you guys start using your kid's chemistry set to manufacture this CRF blocker, you may wish to consider that Corticotrophin Release Factor, if blocked, may very well block the action of ACTH , AdrenoCorticoTrophicHormone, and trust me, you dont want that to happen! The consequence could be the development of a condition, Addison's Disease, that has a lil consequence called: death.

ACTH is released early each morning (a tiny bit) to cause the adrenal glands not to wither away and become unable to secrete several critically-important substances. Without the action of ACTH, the prognosis can be grim, indeed, although life-long use of medications can let such a patient have a relatively normal life.

So, this begs the question: "Just why would a person, for cosmetic reasons, risk such a possible consequence?"

j. a., md

tkj
17th September, 2011 @ 10:58 am PDT

The mice didn't drop dead.

Brian Hall
22nd September, 2011 @ 01:02 pm PDT

But the mice grew hair everywhere on their bodies. Does this mean

that one can develop hairy hands and a hairy ass, too?

John Storojev
23rd September, 2011 @ 12:17 pm PDT

It would be great if it could be used only in places one actually WANTS hair to regrow. A woman who has paid for months and/or years of electrolysis to remove hairs from the face or elsewhere on the body would not be pleased if, in order to alleviate thinning hair on her scalp, all of the body hair were to reappear. (I would personally like to use it on my overly-thin eyebrows, but surely don't want the hair on my legs and arms to come back again.)

CarolinadeWitte
24th September, 2011 @ 06:00 am PDT

I have been conducting an experiment with PS, another CRF blocker, and DMSO as the carrier. From what I have read PS doesn't alter you ACTH levels it only blunts your cortisol levels. I am logging my progress at http://homehairgrow.blogspot.com/ . So far I am about half way through my 9 month trial.

bmartin1134
6th October, 2011 @ 10:42 pm PDT

Great info.

ValerieP
25th December, 2013 @ 10:32 pm PST
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