MinION - $900 usb-powered DNA sequencer on sale this year
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If a target molecule is drawn into or upon the nanopore, it disrupts the flow of ions in a characteristic manner which can be detected and interpreted (Image: Oxford Nanopore)
This diagram shows a protein nanopore set in an electrically resistant membrane bilayer (Image: Oxford Nanopore)
A nanopore is an organic molecule penetrated by a very small (~1-2 nanometer) hole (Image: Oxford Nanopore)
A nanopore embedded in a synthetic polymer membrane collects small molecules for identification (Image: Oxford Nanopore)
The MinION has successfully been used to read the genome of the lambda bacteriophage, about 48500 base pairs in length (Image: Oxford Nanopore)
Sample chips for the MinION incorporate 512 electrically distinct nanopores, each with its own sensing electronics (Image: Oxford Nanopore)
The MinION is the size of a USB memory stick, and obtains both power and computer analysis from a normal laptop computer (Image: Oxford Nanopore)
Article Summary
At the Advances in Genome Biology and Technology 2012 conference (AGBT), Oxford Nanopore Technologies Ltd. announced it is entering the gene-sequencing battle with a disposable DNA sequencer that will sell for under $900 in the second half of 2012. The USB-size sequencer is called the MinION (min-ion), and has already demonstrated the potential to bring genome sequencing and personalized medicine out of the lab and into physicians’ offices.
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