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Experimental dressing directs the growth of blood vessels over wounds

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December 19, 2011

The growth of these blood vessels was caused and directed by the microvascular stamp

The growth of these blood vessels was caused and directed by the microvascular stamp

In the not-too-distant future, wounds may be covered not just with regular bandages, but with special "microvascular stamps" that promote and direct the growth of new blood vessels. A team of scientists from the University of Illinois have already created such a dressing, which could ultimately have applications far beyond the healing of cuts.

The stamp measures approximately one centimeter across, and is made from layers of a hydrogel containing polyethylene glycol polymer and edible methacrylic alginate gelatin. Its other key ingredient, however, is living cells. These are said to release growth factors in a more sustained and targeted manner than has been possible with previous dressings that contained growth factors alone, without cells.

The growth factors are able to permeate the underside of the stamp through channels of various sizes. When the stamp was tested on the surface of a chicken embryo, the network of new blood vessels that formed after one week mirrored the pattern of those channels.

An obvious use for the stamp would be as a covering for wounds such as surgical incisions, which it would likely heal faster, with less scarring. The U Illinois researchers, however, also believe that it could serve to direct new blood vessels around blocked arteries, increase the blood flow in poorly-vascularized tissue, and "normalize" the blood vessels feeding a tumor, in order to improve the delivery of anti-cancer drugs.

A paper on the research is soon to be published in the journal Advanced Materials.

About the Author
Ben Coxworth An experienced freelance writer, videographer and television producer, Ben's interest in all forms of innovation is particularly fanatical when it comes to human-powered transportation, film-making gear, environmentally-friendly technologies and anything that's designed to go underwater. He lives in Edmonton, Alberta, where he spends a lot of time going over the handlebars of his mountain bike, hanging out in off-leash parks, and wishing the Pacific Ocean wasn't so far away.   All articles by Ben Coxworth
2 Comments

If you're interested in the science behind the story, we've made the original article free to access at http://dx.doi.org/10.1002/adma.201103207 .

Dave Flanagan, Advanced Materials

Facebook User
20th December, 2011 @ 05:51 am PST

Thanks, David))

Renārs Grebežs
21st December, 2011 @ 12:47 am PST
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