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New hormone mimics the effects of physical exercise

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January 18, 2012

Potentially, if turned into a viable drug, irisin could induce the benefits of a workout w...

Potentially, if turned into a viable drug, irisin could induce the benefits of a workout without the workout (Photo: iStock)

A group of researchers at Dana-Farber Cancer Institute and Harvard Medical School, led by Bruce Spiegelman and Pontus Boström, have discovered a hormone that mimics some of the results of a workout by facilitating the transformation of white fat into brown fat. While the purpose of the former is to accumulate excess calories, the latter is used to produce heat. Irisin, named after the Greek goddess Iris, could one day help address obesity and diabetes. However, there is still a long way to go before the hormone is made into an actual drug.

Irisin occurs naturally both in humans and in mice, and its levels surge with physical exercise. Mice have to spend three weeks running on a wheel for the hormone to accumulate in their blood. For humans, the same happens after ten weeks of systematic exercising. A placebo-controlled study showed that boosting the levels of the hormone artificially in mice may induce some of the benefits that would normally be caused by a workout. The cells of the mice injected with irisin needed more oxygen and burned more calories. Obese mice lost several grams within the first ten days from the injection.

The treatment also had a positive effect on the regulation of blood sugar levels, which links the hormone to diabetes prevention. What's more, Spiegelman's team plans to investigate the potential of irisin to advance the treatment of diseases such as muscular dystrophy and muscle wasting. "We are hopeful, though we have no evidence, that this hormone may embody some of the other benefits of exercise, perhaps in the neuromuscular system," he says.

This sounds very promising, but there is still a lot to be done before an irisin-based drug comes to a pharmacy near you. First, whether or not irisin will have the same beneficial effects on humans still remains to be seen. Second, making it into an actual drug may turn out to be very challenging, as pointed out by MIT professor Harvay Lodish. Adiponectin, a hormone Lodish discovered back in the early 1990s, also seems to play a role in staving off obesity and diabetes. It is correlated with the body mass index (BMI) and it increases the metabolic rate in mice without raising the food intake. Still, so far all the attempts at converting the full size adiponectin protein into a viable drug have failed.

Professor Spiegelman, however, is optimistic. In fact, he's optimistic enough to have set up a separate company, called Ember Therapeutics, to conduct brown fat-related research that includes studies on the effects of irisin. Supported by Third Rock Ventures, the company raised US$34 million in the first round of financing. We do hope that all this money and brain power will eventually lead to a treatment for obesity and diabetes. That said, we do recognize that there might be more to it than just swallowing a pill.

We are far from advocating the medicalization of serious social issues, and we warmly encourage our readers to exercise on a regular basis (at least until the magic pill is out, that is).

About the Author
Jan Belezina Formerly in charge of Engadget Poland, Jan Belezina's long time fascination with the advance of new technology has led him to become Gizmag's eyes and ears in Eastern Europe.   All articles by Jan Belezina
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16 Comments

Or you could get off your bum and do actual exercise. While doing that you could eat less too. We already have a cure for obesity. What we need is a cure for pathological foolishness.

Scion
18th January, 2012 @ 05:00 pm PST

"However, there is still a long way to go before the hormone is made into an actual drug."

Drug?! I want it made into candy!

Tysto
18th January, 2012 @ 06:53 pm PST

I know that obesity is a problem now, and there are many supposed remedies - drugs, diets, TV exercise gadgets, etc - out there, but. Scion is right: ultimately the solution is a body in motion burning more calories than it takes in! All that said, could Gizmag have chosen a more cringe inducing picture for the article??? Argh!!!

RonLee
19th January, 2012 @ 09:38 am PST

In Euripides' play Heracles, Iris appears alongside Madness, cursing Heracles with the fit of madness in which he kills his three sons and his wife Megara.

Thus an appropriately named drug. Science, in its reductionist ways, does not see the dangers it creates alongside of a replacement to exercise, sensible eating.

ADVENTUREMUFFIN
19th January, 2012 @ 01:05 pm PST

Both Scion and RonLee show their ignorance when it comes to obesity. To them, the solution is simple: just get out and exercise.

But for many it's not that simple. For many, even exercising one hour a day, every day will do little if nothing. A potential drug like this is geared toward those who are genetically behind the eight ball when it comes to weight loss. As a matter of fact, all "extreme" versions of weight loss (liposuction, banding, stapling, etc.) are not designed for the lazy, but for the genetically unfortunate.

And for the rest of us, sometimes it's simply not feasible to get in any sort of exercise. I personally know people who have a 3-hour round-trip commute to work, plus they work from home and spend time with their families, which leaves very little time for them to exercise. Should they just quit their jobs? Ignore their families? Let their homes fall to ruin? Something's gotta give, and for many of us, exercise is the easiest to drop and the one we'll miss the least.

Brian Brehart
19th January, 2012 @ 01:51 pm PST

"Or you could get off your bum and do actual exercise. While doing that you could eat less too."

Well, I thought the same until I started to put up 20 kg without change in lifestyle, no matter how much I exercised and what diet I tried (e.g wholefood, high-protein, low-fat, low-carb, vegetarian). Of course, I could settle for a 1500kcal/day diet. Which by the way gives not only constant hunger, headaches and an overall feeling of having a flu. It also reduces my IQ which is unfortunate, if you're a software designer. And as soon as I stop, weight goes up again.

The situation for me seems to be like this: I'm somehow fixed at my weight, I can only transfer kilos from fat to muscles (or back).

On the other hand, there are people that don't do sport, eat everything the doctor warns you about and stay skinny. Maybe some fat guys just want the same chance even though their genes think different.

EinSascha
19th January, 2012 @ 03:04 pm PST

Obesity is multi factoral, obesity drugs, cholesterol reducing drugs have been a blessing to many, and they have few side effects. At the same time, everyone should do regular exercise.

Dawar Saify
19th January, 2012 @ 04:52 pm PST

Fat people are sinners; SINNERS!!! You just need to look at the grinning abomination, illustrating the article, scoffing pills with contempt for temperance, forbearance and God's devine law to see that!!! And as one such sinner myself I personally will not risk being unfairly tolerated by decent, God-fearing folk just to shed a few pounds and live a few extra years.

Snake Oil Baron
19th January, 2012 @ 05:55 pm PST

SOUNDS AS IF THE HOLY GRAIL HAS BEEN DISCOVERED.....HALELUYAH

RAFAEL SCHLOSER
19th January, 2012 @ 09:09 pm PST

I'm into week 8 of a 10 week workout program (TSC transformation super challenge) and let me tell you, exercise is painful. I'm surprised to discover that at less than 10 weeks I still won't have accumulated any measurable amount of Irisin.

I have lost several inches, but not much weight. The biggest effect I've found so far is that (1) I ache all over all the time and (2) I have surprisingly better muscle tone and much more strength than I've ever had. I must have lost a lot of fat but it'll take me another 10 weeks at least to get rid of my midriff fat to show off any abs. The point about lack of time really hits home, it takes me about an hour to do a 20 minute workout when you factor in psyching up; doing it; cooling down; and clean-up shower afterwards. I imagine this pill, if and when it ever materializes, will only be available by prescription and only for people who are really in trouble, because I can easily see it being abused to no end. One thing the pill will never be able to do is get you that crucial conditioning. For instance, at the pharmacy a few days ago I tried out the blood pressure machine and was astonished to find my pulse rate is now down to 47 beats per minute. In the past it was always 80 bpm or higher. The benefits of exercise is truly shocking, but so too are the body pains and aches and of course I cannot stomach those ice baths they recommend.

Grunchy
19th January, 2012 @ 09:34 pm PST

For those of us who have worked hard many times to loose weight (and in many cases never really succeeded) this could be a major boon. Excising is and always will be important, but for people with exercise induced asthma, widely variable sleep schedules, poor blood sugar regulation, or just a genetic propensity toward weight gain, this could be a big step toward looking and feeling healthier with the kind of moderate exercise that actually improves health instead of destroying it.

Charles Bosse
20th January, 2012 @ 10:14 am PST

Increase risk of developing lipomas/Hibernoma I assume.

Paul Hutchinson
25th January, 2012 @ 04:26 am PST

Um, do you see obese people in starving countries? do they have hormone problems and "look" fat?? yeah, it's difficult, you have a economy that provides jobs in resturants, fast food and otherwise, and all that advertisments to entice to eat all that good food, of course you don't have to....it can be a real battle, maybe this is the boost some people need.

junbug20
1st February, 2012 @ 08:07 am PST

This is just a way for Big Pharma to get more money from us... instead, read "The Primal Blueprint" and take control of your diet and your own health.

Dave Kristof
4th February, 2012 @ 10:15 am PST

Nobody has mentioned the hormone HCG. It's been effectively used for weight loss since the '50's.

Don Juan
11th March, 2012 @ 05:47 pm PDT

America is the only country in the world where the majority of its population is dying from an epidemic of obesity. This research was probably funded by the companies that make processed food. Great....now people can consume more and more food now while the rest of the world starves....

RESISTANCE
21st June, 2012 @ 10:35 am PDT
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