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Brazilian researchers develop new anti-inflammatory for severe pain

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July 3, 2012

The main breakthrough of the research is the successful synthesizing of a protein produced...

The main breakthrough of the research is the successful synthesizing of a protein produced by the human body (Photo: Shutterstock)

Researchers at Butantan Institute in São Paulo, Brazil, have developed a powerful new anti-inflammatory to relieve hard-to-control pain. Initial tests have confirmed the efficacy of the medication, which is based on a protein found in the blood.

The main breakthrough of the research is the successful synthesizing of a protein produced by the human body, the calcium binding S100A9. Under certain conditions, this protein is used by our bodies to keep pain under control. To make the medication, the scientists discovered that only a small part of the protein is required, which leads to reduced production costs.

According to researcher Renata Giorgi, the discovery represents an important step forward in relation to drugs available in Brazil. In particular the new drug offers two important advantages: it is more powerful and it can be administered orally.

“We’ve discovered that some white blood cells contain a protein that can inhibit pain that stem from an inflammation. By synthesizing a small piece of that protein, we managed to make its dispensation viable,” said Giorgi. She added that the treatment of chronic pain in cases such as nerve lesions is difficult because drugs like morphine lose their efficacy with time.

The drug may not become available for several years and the next stage in the ongoing research is to test for toxicity. In the case of analgesics (painkillers), testing the patient’s level of tolerance is critical as the dosage of such drugs may have to be increased if the patient develops resistance to them.

Source: Brasil.gov.br

About the Author
Antonio Pasolini Brazilian-Italian Antonio Pasolini graduated in journalism in Brazil before heading out to London for an MA in film and television studies. He fell in love with the city and spent 13 years there as a film reviewer before settling back in Brazil. Antonio's passion for green issues - and the outdoors - eventually got the best of him and since 2007 he's been writing about alternative energy, sustainability and new technology.   All articles by Antonio Pasolini
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2 Comments

Good luck to 'em. I know someone who would seriously benefit from a medicine of this nature.

limbodog
5th July, 2012 @ 07:46 am PDT

I could use something like this! I have Hperjointmobility Ehler-Danlos Syndrome. I've had over 40 surgeries in my life and have constant chronic pain.

Kelly Priest
6th July, 2012 @ 07:44 am PDT
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