Adult stem cells used to induce the natural hair growth cycle in hairless mice
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The bio-engineered follicle germ transplantation method allowed the scientists from the Tokyo University of Science to regenerate hair growth in hairless mice
The observed growth of bioengineered hairs
Histological analyses of bioengineered vibrissa follicles
Intracutaneus transpantation of the bioengineered follicle germ at high density
The resultant hair density is satisfactory
A previously hairless mouse following an implantation of bioengineered hair follicles recreated from adult tissue-derived stem cells
A previously hairless mouse following an implantation of bioengineered hair follicles recreated from adult tissue-derived stem cells - side view
A previously hairless mouse following an implantation of bioengineered hair follicles recreated from adult tissue-derived stem cells - rear view
A previously hairless mouse following an implantation of bioengineered hair follicles recreated from adult tissue-derived stem cells - side view
A previously hairless mouse following an implantation of bioengineered hair follicles recreated from adult tissue-derived stem cells - front view
A previously hairless mouse following an implantation of bioengineered hair follicles recreated from adult tissue-derived stem cells - front view
A previously hairless mouse following an implantation of bioengineered hair follicles recreated from adult tissue-derived stem cells - side view
The method allows for the full restoration of the continuous hair growth cycle
The microscopic view of the bioengineered hair shafts
The implanted hair follicles formed the correct structures and skin connections, while stem and progenitor cell niches were recreated
Article Summary
Researchers lead by Professor Takashi Tsuji from the Tokyo University of Science have successfully induced the natural hair growth and loss cycle in previously hairless mice. They have achieved this feat through the implantation of bioengineered hair follicles recreated from adult-tissue derived stem cells. While these results offer new hope for curing baldness, the work has broader implications, demonstrating the potential of using adult somatic stem cells for the bioengineering of organs for regenerative therapies.
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