Adult stem cells used to induce the natural hair growth cycle in hairless mice


April 23, 2012

A previously hairless mouse following an implantation of bioengineered hair follicles recreated from adult tissue-derived stem cells

A previously hairless mouse following an implantation of bioengineered hair follicles recreated from adult tissue-derived stem cells

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Researchers lead by Professor Takashi Tsuji from the Tokyo University of Science have successfully induced the natural hair growth and loss cycle in previously hairless mice. They have achieved this feat through the implantation of bioengineered hair follicles recreated from adult-tissue derived stem cells. While these results offer new hope for curing baldness, the work has broader implications, demonstrating the potential of using adult somatic stem cells for the bioengineering of organs for regenerative therapies.

The method devised by Professor Tsuji’s team involves reconstructing hair follicle germs from adult epithelial stem cells and cultured dermal papilla cells (dermal papilla are nipple-like projections at the base of hairs) and implanting these germs within or between skin layers. To recreate the desired hair densities – normally about 120 hair shafts per square centimeter (0.15 square inch) or 60-100 hair shafts per square centimeter following a conventional hair transplantation method – 28 bioengineered follicle germs were transplanted onto a circular patch of cervical skin measuring 1 cm (0.39 in) in diameter. The resulting hair density of 124 hair shafts per square centimeter (plus or minus 17 shafts) turned out to be satisfactory, but there was more good news.

Far more importantly, the implanted follicle germs developed all the proper structures and formed correct connections with the surrounding host tissues, including epidermis, arrector pili muscle and nerve fibers. Also, the stem and progenitor cells along with their niches were recreated in the bioengineered follicles, making a continuous hair-growth cycle possible.

The method has been shown to work with all types of hair follicles, regardless of function, structure and color (depending on the type of the origin follicle). In fact, some features of the hair shaft, such as pigmentation, may be controlled – fancy a new permanent hair color?

Although more research is still necessary (such as further study of stem cell niches and optimizing the way origin follicles are to be sourced for clinical applications), the study constitutes another milestone on the way to next generation regenerative therapies.

Source: Tokyo University of Science

About the Author
Jan Belezina Formerly in charge of Engadget Poland, Jan Belezina's long time fascination with the advance of new technology has led him to become Gizmag's eyes and ears in Eastern Europe. All articles by Jan Belezina

I'm going to have to post this one on my personal blog - if for no other reason than my wife thinks this mouse is cute as all getout.


Assuming of course that the recipient is the adult the cells are sourced from no anti-rejection drugs are needed ether.


sign me up

Patrick Vick

Who ever cures baldness will become the richest person on earth.


Based on recent research I have been told of, most of the rejection problems have been solved. The doctors have told my best friend who needs a pancreas transplant there is minimal danger of rejection and she will not have to be on the anti-rejection drugs. I am not sure but if I understood her correct they will do two procedures. The first procedure will implant stem cells from the donor and the second will be the pancreas transplant. I just was not sure if the two procedures were done at the same time.

All I know is she is hopeful for the first time in 4 years.

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