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Inexpensive card-sized device runs 50 blood tests in seconds

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December 31, 2012

The V-chip is an inexpensive credit card-sized device, that can instantly test a single dr...

The V-chip is an inexpensive credit card-sized device, that can instantly test a single drop of blood for up to 50 different substances

Ordinarily, when medical clinicians are conducting blood tests, it’s a somewhat elaborate affair. A full vial of blood must be drawn, individual portions of which are then loaded into large, expensive machines such as mass spectrometers. The results are usually quite accurate, but they’re not instantaneous, and require the services of trained personnel in a well-equipped lab. That may be about to change, however. Scientists from Houston’s Methodist Hospital Research Institute and MD Anderson Cancer Center have created a credit card-sized gadget, that can instantly check a single drop of blood for up to 50 different substances – and it costs about US$10.

Developed by a team led by Dr. Lidong Qin, the device is known as a volumetric bar-chart chip – or the V-chip, for short.

It consists of two thin sheets of glass, with a series of 50 tiny wells sandwiched between them. Each of those wells can contain different types of antibodies, selected for their tendency to bind to specific proteins. All of the wells also contain an enzyme known as catalase, along with hydrogen peroxide, and a dye. A sample drop of blood or other bodily fluid is placed in another well, at one end of the V-chip.

Initially, all of the wells are isolated from one another. When the two glass plates are slid against one another, however, the wells are linked by one long continuous zig-zagging microfluidic channel. The sample fluid flows along that channel, going through each of the wells as it does so.

When the antibodies in any one of the wells react with the targeted substance – such as insulin, or a specific drug or virus – the catalase is activated, which in turn splits the hydrogen peroxide into water and oxygen gas. That gas pushes the dye up a column linked to the well, where it can be seen by the user. The higher the dye goes in that column, the greater the amount of the substance in the sample. Viewed as a whole, the V-chip appears as a bar chart, indicating the relative amounts of the various targeted substances.

Although lab tests would likely still be the way to go for the most accurate, detailed results possible, the V-chip could prove very useful in places like developing nations, where laboratories are inaccessible or non-existent. It could also find use in emergency rooms or ambulances, where caregivers need to detect the presence of specific drugs or poisons as fast as possible.

Qin and his team are now working on making the V-chip more user-friendly. A paper on the research was recently published in the journal Nature Communications, which also features a video on the device.

Source: Methodist Hospital Research Institute via Dvice

About the Author
Ben Coxworth An experienced freelance writer, videographer and television producer, Ben's interest in all forms of innovation is particularly fanatical when it comes to human-powered transportation, film-making gear, environmentally-friendly technologies and anything that's designed to go underwater. He lives in Edmonton, Alberta, where he spends a lot of time going over the handlebars of his mountain bike, hanging out in off-leash parks, and wishing the Pacific Ocean wasn't so far away.   All articles by Ben Coxworth
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4 Comments

Looks useful for disaster relief as well.

Slowburn
31st December, 2012 @ 06:36 pm PST

Vit D check would be useful.

Stewart Mitchell
2nd January, 2013 @ 06:28 am PST

So two unique V-chips could do 100 tests? I think for follow-up visits to the doctor, or even first visits, this would be a good way to at least get a sense of how things are and to see if there are any "red flags" in the results. Two drops is a lot easier to deal with than a few flasks, and I would guess $20 bucks is easier to handle than the going rate for blood work.

Bruce H. Anderson
2nd January, 2013 @ 08:21 am PST

But would Dexter use it? ;-)

mokkybear54
7th January, 2013 @ 02:13 am PST
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