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University of York

Images showing insulin (blue) molecules binding with insulin receptors (yellow) could help...

Despite decades of study, scientists remained unsure as to how insulin binds to the insulin receptor on the surface of cells to allow them to take up sugar from the blood and transform it into energy. Now, a definitive answer has now been found with a team of scientists capturing the first three-dimensional images of insulin “docking” to its receptor. It is hoped that the new knowledge can be exploited to develop new and improved insulin medications to treat type 1 and type 2 diabetes.  Read More

Findings that a variant of the CIZ1 protein is present in lung cancers could lead to the d...

While the overall lung cancer five-year survival rate in the U.S. is 15 percent, the odds of survival increase significantly with early detection. However, the expense or invasiveness of current screening methods and the lack of symptoms at early stages of the disease means most people aren’t diagnosed until the cancer is well advanced. Findings by researchers at the University of York could pave the way for a simple blood test that would detect the disease even in its early stages.  Read More

Unlocking the three-dimensional structure of the enzyme endomannosidase could lead to new ...

Viruses can enter the body via a number of pathways and while scientists have known how to block the main one used by viruses such as HIV, Hepatitis C, Dengue Fever and West Nile virus for some time, these viruses are able to bypass this main pathway to replicate and cause disease via a second pathway by hijacking an enzyme known as endomannosidase. Now an international team of researchers has determined the three-dimensional structure of the enzyme endomannosidase, opening the door for new treatments to a variety of deadly viruses through the development of inhibitors that block this bypass route.  Read More

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