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Regenerative Medicine

Researchers have regrown hair, cartilage, bone and soft tissues in a mouse model (Photo: R...

Anyone who has left youth behind them knows that bumps and scrapes don't heal as fast as they used to. But that could change with researchers at the Stem Cell Program at Boston Children's Hospital finding a way to regrow hair, cartilage, bone, skin and other soft tissues in a mouse by reactivating a dormant gene called Lin28a. The discovery could lead to new treatments that provide adults with the regenerative powers they possessed when very young.  Read More

A cross-section of Organovo's 3D bio-printed liver tissue

Back in 2009, we heard about a 3D bio-printer that had been developed through a collaboration between Australian engineering firm Invetech, and Organovo, a San Diego-based regenerative medicine company. The device incorporates two print heads – one for placing human cells, and the other for placing a hydrogel, scaffold, or support matrix. At the time, the hope was that the printer could someday be used to create organs for transplant purposes. This week, Organovo announced that it has succeeded in using the device to create three-dimensional functioning human livers – albeit tiny ones.  Read More

Researchers have found that oxygen-containing free radicals aid rather than harm cell rege...

Researchers at the University of Manchester have found that Reactive Oxygen Species (ROS) – oxygen-containing free radicals that are commonly believed to be harmful to cells – actually play a vital role in the regeneration of the tails of tadpoles. The finding could have profound implications for the healing and regeneration of human tissue.  Read More

The experimental 3D printer, which combines electrospinning and ink jet printing technolog...

Generally speaking, injured cartilage doesn’t heal well ... if at all. In recent years, however, scientists have successfully regrown cartilage at injury sites, using things like hydrogel, microspheres and collagen-based nano-scaffolding. Now, a team of scientists led by Prof. James Yu of North Carolina's Wake Forest Institute for Regenerative Medicine have developed something else – a 3D printer that creates implantable cartilage.  Read More

Scientists have used transplanted cells from disabled dogs' noses to restore their ability...

Scientists from the University of Cambridge’s Veterinary School, working with colleagues from the UK Medical Research Council’s Regenerative Medicine Centre, have got disabled dogs walking again. More specifically, they’ve used the dogs’ own cells to repair their spinal cord injuries, and at least partially restored the functionality of their back legs. The researchers believe that the process shows promise for use on physically challenged humans.  Read More

The biocompatible cryogel rapidly regains its original memorized shape, size, and volume u...

Biocompatible scaffolds, like those developed to stimulate the repair of heart tissue and bone and cartilage in the body, would normally need to be implanted surgically. Now bioengineers at Harvard University have developed a compressible bioscaffold that can be delivered via a syringe before popping back to its original shape inside the body. The material is also able to be loaded up with drugs or living cells that are gradually released as the material breaks down.  Read More

Printing blood vessels: the future? (Photo: Biomedical Nanotechnology Laboratory, Chen Res...

3D printing technologies have come a long way since their earliest incarnations as rapid product prototype makers. It's now shaping up as the next disruptive technology and in medical science, 3D printing has huge potential. The latest advance comes from University of California, San Diego Nanoengineering Professor Shaochen Chen, whose group has demonstrated the ability to print three-dimensional blood vessels in seconds. If the technique proves scalable, it could revolutionize regenerative medicine.  Read More

Chimeric monkeys Roku, Hex and Chimero (not pictured) are the first three primates ever to...

Scientists have reached a major milestone in the field of stem cell research. A team at the Oregon National Primate Research Center (ONPRC) say their work has led to the first successful birth of three chimeric monkeys - monkeys developed from stem cells taken from two separate embryos.  Read More

Male urinary anatomy illustration showing the flow of urine from the bladder through the u...

In a move that augurs well for the engineering of replacement tissues and organs, researchers have reported the world's first successful implantation of urinary tubes grown in the laboratory using the patients' own cells. Between March 2004 and July 2007, the research team from the Institute for Regenerative Medicine at Wake Forest University Baptist Medical Center and colleagues engineered urinary tubes, or urethras, for five boys aged 10 to 14 using cells from the boys' own bladders to replace damaged segments. Tests showed the engineered tissue remained functional throughout the median six-year follow-up period.  Read More

Scientists from have generated pluripotent stem cells from horses for the first time (Phot...

For the first time ever, scientists from the University of Montreal and Mount Sinai Hospital have generated pluripotent stem cells from horses. Pluripotency refers to a cell's ability to become any of the various other types of cells found within the body, and the ability to be able to grow such cells in a laboratory setting has great implications for the field of regenerative medicine. Not only does this latest accomplishment potentially mean big things for sick or injured horses, but it could also pave the way for lab-based human stem cell treatments.  Read More

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