The blood-brain barrier is an almost impenetrable membrane that surrounds vessels in the brain and stops harmful particles from entering. The trouble is that it doesn't discriminate, at the same time making it very difficult for beneficial molecules like medication to pass through. But researchers have now non-invasively breached the barrier for the first time in a human subject, delivering chemotherapy drugs to a brain cancer patient with a high level of precision and paving the way for improved treatments and fewer side effects for sufferers of neurological disorders.
A natural enzyme called catalase may prove hugely significant in treating neurological disorders such as Parkinson's. These extremely potent antioxidants can tackle neuron-killing inflammation with an effectiveness unparalleled by small molecule drugs. But there's a problem, they are big. So big that getting them through the blood-brain barrier for delivery straight to the brain is nearly impossible. But researchers have now discovered that loading them into tiny, naturally occurring bubbles allows them to sneak past the brain's defenses, pointing to the possibility of improved treatments for such conditions.