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Muscular Dystrophy

Scientists have devised a method of lengthening telomeres, allowing cells to divide more t...

Researchers at the Stanford University School of Medicine have developed a new procedure to increase the length of human telomeres. This increases the number of times cells are able to divide, essentially making the cells many years younger. This not only has useful applications for laboratory work, but may point the way to treating various age-related disorders – or even muscular dystrophy.  Read More

Dr Subha Raman led a team of scientists in exploring the effects of combining heart failur...

Signs of Duchenne muscular dystrophy (DMD) can start to appear in boys as young as six, leading to deterioration of the heart muscles and ultimately death. Pharmaceuticals aimed at controlling high blood pressure have been used to treat the one in 3,500 young males suffering from the condition, but a new study suggests that a novel combination of these drugs could slow the decline in heart function earlier on, and in promising new ways.  Read More

A new gene editing technique shows promise for the treatment of Duchenne muscular dystroph...

Researchers at the University of Texas (UT) Southwestern Medical Center have developed a technique that corrects a mutation leading to Duchenne muscular dystrophy (DMD). The technique, called CRISPR/Cas9-mediated genome editing, removes the mutation entirely in mice, and could have far-reaching consequences in the treatment of muscular dystrophy in people.  Read More

Pumped-up muscle tissue (in blue) in a high performing 'mighty mouse'

He can't fly just yet, but a team of scientists have made a big step towards creating a real-life Mighty Mouse. Researchers at the Salk Institute for Biological Studies, along with two Swiss institutions, Ecole Polytechnique Federale de Lausanne (EPFL) and the University of Lausanne, created a batch of super-strong mice and worms by tweaking a gene that normally inhibits muscle growth.  Read More

Muscle cells of untreated mice with muscular dystrophy (left) show little utrophin in cell...

Duchenne Muscular Dystrophy is the most common and severe childhood form of muscular dystrophy (MD), affecting one in 3,500 boys. The disease progressively weakens muscles cells and tissues until muscle degradation is so severe that the patient dies, most often in their late teens or twenties. Scientists at Brown University in Providence, Rhode Island and the University of Pennsylvania, hope their research into the human protein, biglycan, will ultimately improve the condition of muscular dystrophy sufferers. Their studies have shown that biglycan significantly slows muscle damage and improves function in mice with the Duchenne genetic mutation. Human clinical trials will be the next step.  Read More

The no longer wheelchair-bound Hayden Allen puts REX through its paces

Seemingly simple things like talking to people at eye level and reaching things on shelves can be a huge drawback for those in wheelchairs. Sitting in a wheelchair for extended periods can also lead to the increased risk of certain infections and blood circulation problems. A robotic exoskeleton called REX puts wheelchair users back on their feet, enabling a person to stand, walk and go up and down stairs and slopes.  Read More

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