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Insulin

Iron nanoparticles (blue), tethered to the ion channel seen (red) by a protein (green) hav...

Sufferers of type 1 diabetes regularly need to inject themselves with insulin in order to regulate levels of sugar in their blood, a process that is invasive and requires particular care. But a new study conducted at the Rensselaer Polytechnic Institute suggests that more comfortable treatment methods may not be all that far away, with scientists remotely manipulating insulin production in mice using electromagnetic waves.  Read More

A single molecule made by combining three hormones has been found to effectively cure obes...

In 2012, we covered work led by Professor Richard DiMarchi that showed linking two hormones into a single molecule held promise as a treatment for obesity. DiMarchi followed this up last year by combining the properties of two endocrine hormones to provide an effective treatment for both obesity and adult-onset diabetes. Continuing in this vein, DiMarchi has now co-led a study whereby obesity and diabetes were effectively cured in lab animals by adding a third hormone to the molecular mix.  Read More

Clinical trials are set to begin in 2015 on the potential of a common blood pressure drug ...

A study at the University of Alabama at Birmingham (UAB) has shown that verapamil, a drug widely used to treat high blood pressure, irregular heartbeat and migraine headaches, is able to completely reverse diabetes in animal models. The UAB team will now move onto clinical trials to see if the same results are repeated in humans.  Read More

Orgenesis' approach involves harvesting the patient's own liver cells and converting them ...

When pancreatic islet allo-transplantation therapy was first introduced, it provided hope for countless diabetics tired of daily insulin injections. While the technology has delivered on much of its promise, Tel Aviv-based regenerative medicine firm Orgenesis is currently developing a treatment of its own, that it claims addresses much of the shortcomings of islet therapy. In a nutshell, its approach involves converting the patient’s own liver cells into cells that produce insulin.  Read More

Researchers at the Salk Institute have found that the FGF1 protein shows promise for the d...

There are numerous research efforts underway to develop new treatments and improve the lives of people suffering type 2 diabetes, whose ranks have increased dramatically in recent decades due in large part to the so-called obesity epidemic. A new generation of safer and more effective diabetes drugs could be in the offing with researchers at the Salk Institute discovering that when mice with diet-induced diabetes were given a single injection of a protein, their blood sugar levels were restored to a healthy range for more than two days.  Read More

A new study has found that changes in ambient temperature can influence the concentration ...

The discovery that lowering your body temperature leads to an increase in a certain type of "good" fat might have some ditching the diet books and shedding a layer of clothing instead. A study conducted at the National Institute of Health (NIH) in Washington has demonstrated that changes in ambient temperature affects brown fat levels in humans, pointing to potential treatment options for the weight-wary and sufferers of diabetes.  Read More

Replenishing the insulin-secreting beta cells found in the pancreas could lead to a more p...

Type 1 diabetics suffer from a lack of beta cells in the pancreas, which are responsible for insulin production. Although glucose monitoring and insulin injections allows the disease to be managed, finding a way to replenish these beta cells would offer a more permanent solution. Scientists at Gladstone Institutes in San Francisco have provided hope for just such a treatment by developing a technique to reprogram skin cells into insulin-producing beta cells.  Read More

Orally-ingested insulin layersomes could eventually replace injections  (Photo: Shuttersto...

Help could be on the way for the hundreds of millions of diabetics who are tired of giving themselves daily insulin injections. Scientists from India's National Institute of Pharmaceutical Education and Research have recently had success in orally delivering insulin to rats' bloodstreams.  Read More

The nano-network that releases insulin in response to changes in blood sugar

Aside from the inconvenience of injecting insulin multiple times a day, type 1 diabetics also face health risks if the dosage level isn’t accurate. A new approach developed by US researchers has the potential to overcome both of these problems. The method relies on a network of nanoscale particles that once injected into the body, can maintain normal blood sugar levels for more than a week by releasing insulin when blood-sugar levels rise.  Read More

Led by Fàtima Bosch (fifth from left), a University of Barcelona research team has cured d...

Researchers from the Universitat Autònoma de Barcelona (UAB) have claimed a first by successfully using a single session of gene therapy to cure dogs of type 1 diabetes. The work has shown that it is possible to cure the disease in large animals with a minimally-invasive procedure – potentially leading the way to further developments in studies for human treatment of the disease.  Read More

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