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Science

Domestic tomato genome sequenced in full

The scientists of the aptly-named Tomato Genome Consortium have successfully sequenced the genome of the domestic tomato (Solanum lycopersicum), specifically the domestic cultivar known as Heinz 1706. The genome is made up of 35,000 genes spread over 12 chromosomes. In addition to presenting a "high quality" genome of the species, the researches also produced a draft sequence of its closest wild relative, the currant tomato (Solanum pimpinellifolium).Read More

Science

World's largest human cancer genome database released

As part of an ongoing effort to facilitate swifter progress in the fight against cancer and other related diseases, the St. Jude Children's Hospital-Washington University Pediatric Cancer Genome Project has released a vast amount of human cancer genome data, which is now available to scientists globally. The volume of information offered amounts to more than double the data previously open to scientists from all the other human genome sources combined. Read More

Medical

New concept could lead to low-cost DNA sequencing in everyday clinical practices

Doctors and scientists wishing to decode a human genome can now do so in a day for US$1,000 a pop using the recently-released Ion Proton sequencer. With a price tag of $149,000, though, the machine isn’t cheap – nor is it the be-all and end-all of desktop gene sequencing. For one thing, the tiny $900 MinION sequencer should be available soon. Also, a team of scientists from Oak Ridge National Laboratory and Yale University have now developed a concept of their own, which could end up providing an even less expensive high-speed sequencer.Read More

Health & Wellbeing

MinION - $900 usb-powered DNA sequencer on sale this year

At the Advances in Genome Biology and Technology 2012 conference (AGBT), Oxford Nanopore Technologies Ltd. announced it is entering the gene-sequencing battle with a disposable DNA sequencer that will sell for under $900 in the second half of 2012. The USB-size sequencer is called the MinION (min-ion), and has already demonstrated the potential to bring genome sequencing and personalized medicine out of the lab and into physicians’ offices.Read More

Science

Ion Proton sequencer decodes DNA fast and on the cheap

The mapping of the human genome, announced at the White House back in 2000, had immense impact on biomedical research. It allowed us to gain insights into how biological information is encoded in the genome, helped us understand the biological mechanisms behind cancer and hereditary diseases and enabled us to look much deeper into the history of our own species. These are milestone achievements for humanity as a whole, but they have little or no direct impact on everyday medical treatment. That could be about to change, however, as Life Technologies introduces the Benchtop Ion Proton Sequencer - a machine that may finally deliver the power of genetics into the hands of ordinary doctors.Read More

Medical

Black Death genome reconstructed

It's hard to comprehend the impact of the Black Death. The "Great Pestilence" is believed to have originated somewhere in Northern Asia in the 1330s before hitting Europe in 1347. It killed an estimated 75 million people worldwide - that's around 25 per cent of all humans in existence at the time. Now in an effort to better understand modern infectious diseases, scientist have sequenced the entire genome of the Black Death.Read More

Medical

Proposed health care system would incorporate computer models of patients

The way things currently stand in the field of medicine, doctors often have to try out a number of treatments on any one patient, before (hopefully) finding one that works. This wastes both time and medications, and potentially endangers the patients, as they could have negative reactions to some drugs. In the future, however, all that experimenting may not be necessary. The pan-European IT Future of Medicine (ITFoM) project, a consortium of over 25 member organizations, is currently developing a system in which every person would have a computer model of themselves, that incorporated their own genome. Doctors could then run simulations with that model, to see how various courses of treatment would work on the actual person. Read More

Science

New technology developed for the large-scale editing of DNA

While scientists have long had the ability to edit individual genes, it is a slow, expensive and hard to use process. Now researchers at Harvard and MIT have developed technologies, which they liken to the genetic equivalent of the find-and-replace function of a word processing program, that allow them to make large-scale edits to a cell’s genome. The researchers say such technology could be used to design cells that build proteins not found in nature, or engineer bacteria that are resistant to any type of viral infection.Read More

Health & Wellbeing

Theobroma cacao genome sequenced: Yummier chocolate on the way!

If DNA sequencing never held much relevance for you, consider the benefits likely to flow from the recent sequencing and assembly of the chocolate tree genome. The Theobroma cacao plant is generally regarded as producing the world's finest chocolate, but is particularly vulnerable to disease and not particularly productive, and is hence shunned by risk averse growers. It is hoped the research will not only lead to hardier trees by altering the genes, but will also enable the percentages of cocoa butter, flavonoids, antioxidants, terpenoids and hormones to be regulated. The end result is likely to be smoother, more flavorsome, better smelling and even healthier chocolate. Now that's progress!Read More

Science

New technology promises cheap gene sequencing in minutes

Sequencing an entire genome is currently a highly complex, time-consuming process – the DNA must be broken down into segments and replicated, utilizing chemicals that destroy the original sample. Scientists from Imperial College London, however, have just announced the development of a prototype device that could lead to technology capable of sequencing a human genome within minutes, at a cost of just a few dollars. By contrast, when sequencing of the genome of Dr. James Watson (co-discoverer of the structure of DNA) was completed in 2007, it had taken two years and cost US$1 million.Read More

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