Decision time? Check out our latest product comparisons

Drugs

British drivers will soon face 'zero tolerance' drug driving laws (Photo: Shutterstock)

The UK has put in place some of the strictest drug driving laws on the planet in an effort to get drug-impaired drivers off the roads. Breath screening and blood tests will be used to detect eight illicit drugs at "zero tolerance" levels, and eight further prescription drugs at levels that would begin to impair driving. Naturally, since the British government can’t be seen to encourage recreational drug use, these limits haven’t been put into a practical context. So we contacted several drug testing experts and a forensic pharmacologist to try to work out what they mean. And as it turns out, some drugs will make you illegal to drive long after their physical effects have worn off.  Read More

A new device simulates the way in which the gastrointestinal tract absorbs orally-administ...

Before drugs are tested on humans, they first go through pre-clinical tests on animals. Because humans and animals don't have identical gastrointestinal tracts, however, the way in which the drugs are absorbed by the body often differs between the two. A scientist from the UK's University of Huddersfield hopes to address that discrepancy, with his "gut simulator."  Read More

In testing the fluorescent compound, the team observed a difference in the intensity of th...

Central to the dangers of so-called "date-rape" drugs is the fact that they are difficult to detect. Indeed, GHB, one of the most commonly-used of such drugs, is both colorless and odorless. A team of researchers from the National University of Singapore (NUS) has developed a fluorescent sensor which, when mixed with a drink containing GHB, changes color within 30 seconds, potentially alerting people soon after their drink has been tampered with.  Read More

The ATHENA organ project combines heart, liver, kidney and lung features in a toxicity tes...

A five-year, US$19 million multi-institutional effort is working on developing a "desktop human" that could reduce the need for animal testing in the development of new drugs. The "homo minitus" is a drug and toxicity analysis system that would comprise four human organ constructs interconnected to mimic the response of human organs. The project has now reported success in the development of its first organ construct, a human liver construct that responds to exposure to a toxic chemical much like a real liver.  Read More

Immunofluorescence image shows nanoparticles targeted to endothelial cells – the red parti...

In recent years, we've seen various research efforts looking to specifically target cancer cells as a replacement for the shotgun approach employed by chemotherapy that also damages healthy cells. The trick is to develop a delivery vehicle that identifies and targets only cancer cells, while ignoring the healthy ones. Researchers have found charged polymers have this ability, opening the door for nanoparticles containing cancer-fighting drugs to deliver their payload directly to the cancer cells.  Read More

A nanoparticle delivery mechanism (left) treats tumors in mice more effectively

A common strategy for treating tumors is combining two or more drugs, which has the effect of decreasing toxicity and increasing the synergistic effects between the drugs. However, the efficacy of this kind of cocktail treatment suffers when the drugs require access to different parts of the cell, a bit like fighting a battle by depositing all your archers on the same spot as your infantrymen. By making use of nanoparticle-based carriers, researchers at North Carolina State University are able to transport multiple drugs into cancerous cells optimally and precisely, in maneuvers that any field commander would be proud of.  Read More

Bioinspired magnetically propelled helical microswimmers could deliver drugs at the right ...

If you remember the 1966 science fiction film Fantastic Voyage, you'll recall how miniaturized government agents traveled through blood vessels in a tiny submarine, in their attempt remove a blood clot from a scientist's brain. Synthetic nanomotors that can do the same job have been the subject of numerous research efforts and now University of California, San Diego (UCSD) researchers report that they've created powerful biodegradable "microswimmers" that can deliver drugs more precisely, derived from common plants like passion fruit and wild banana.  Read More

A new test has been developed that could help identify patients using antidepressants who ...

The results of a years-long study with patients on antidepressants may help doctors predict one of the most severe side effects those medications can produce: treatment-emergent suicidal ideation (TESI). The condition is estimated to affect between four and 14 percent of patients, who typically present symptoms of TESI in the first weeks of treatment or following dosage adjustments. So far doctors haven’t had indicators to predict which patients are more likely to develop TESI, but a new test based on research carried out by the Max Planck Institute of Psychiatry in Munich, Germany, could change that.  Read More

Drugs called 'pharmacoperones' can fix the problems that occur when proteins 'misfold'

Proteins adopt their functional three-dimensional structure by the folding of a linear chain of amino acids. Gene mutation can cause this folding process to go awry, resulting in "misfolded" proteins that are inactive or, in worse cases, exhibit modified or toxic functionality. This is the cause of a wide range of diseases, but researchers have developed a technique that fixes these misfolded proteins, allowing them to perform their intended function, thereby providing a potential cure for a number of diseases.  Read More

A newly developed nanoparticle may signal the end of injections for treatment of some comm...

Most of us would swallow a pill before being poked by a needle, yet sufferers of chronic illnesses are regularly required to administer their medicine intravenously. A team of researchers from MIT and Brigham and Women's Hospital (BWH) has developed a new type of nanoparticle that could afford patients the choice – potentially making uncomfortable injections a thing of the past in the treatment of a range of chronic diseases.  Read More

Looking for something? Search our 29,168 articles