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Chemotherapy

MIT's new nanoparticle carries three cancer-fighting drug molecules — doxorubicin is red, ...

Delivering drugs that can knock out tumor cells within the body, without causing adverse side effects, is a tricky busines. It's why scientists have taken to engineering new and creative types of nanoparticles that do the job. Increasing a nanoparticle's ability to carry more drugs expands treatment options, but creating nanoparticles capable of delivering more than one or two drugs has proven difficult – until now. Scientists at MIT report creating a revolutionary building block technique that's enabled them to load a nanoparticle with three drugs. The approach, they say, could be expanded to allow a nanoparticle to carry hundreds more.  Read More

Immunofluorescence image shows nanoparticles targeted to endothelial cells – the red parti...

In recent years, we've seen various research efforts looking to specifically target cancer cells as a replacement for the shotgun approach employed by chemotherapy that also damages healthy cells. The trick is to develop a delivery vehicle that identifies and targets only cancer cells, while ignoring the healthy ones. Researchers have found charged polymers have this ability, opening the door for nanoparticles containing cancer-fighting drugs to deliver their payload directly to the cancer cells.  Read More

Abnormal lymphocyte being attacked by macrophages (upper right), which lead to enhanced gr...

If a locked door must be opened, explosives can be used, but normally it is better to use a key. The conventional treatments for cancer, surgery, radiation, and chemotherapy, have a range of terrible side effects that resemble the use of explosives in search of health. Now a key has been found to treat various forms of leukemia and lymphoma with only very minor side effects. The drug ibrutinib has proven sufficiently safe and effective in early clinical tests by physicians at Ohio State University that it has been given breakthrough drug status by the FDA.  Read More

The Nanostructured Lipid Carrier (NLC) that can be inhaled to deliver an anticancer drug d...

According to American Cancer Society estimates, lung cancer will account for 27 percent of all US cancer deaths in 2013, making it by far the leading cause of cancer death among both men and women. Part of the problem is getting the toxic chemotherapeutic drugs used to treat the cancer into the lungs. A new drug delivery system aims to overcome this problem by allowing the drugs to be inhaled, thereby delivering the drug where it is needed while reducing the harmful effects to other organs.  Read More

Rice University research scientist Ekaterina Lukianova-Hleb adjusts equipment used in expe...

U.S. scientists are developing a technique that will target and kill cancer cells while simultaneously treating others in the same sample. Centered on fine-tuning the use of cancer destroying nanobubbles, the research holds promise for treating cancer patients in a way that’s far more targeted than chemotherapy.  Read More

The results of a test of several chemotherapy drugs on a lung cancer tumor (Photo: Presage...

Seattle’s Presage Biosciences has developed a device which introduces small amounts of different chemotherapy drugs into a patient's tumor. The tumor is inspected after removal and the most effective of the drugs are used for post-surgical chemotherapy, resulting in more efficient, personalized cancer treatments. The new device is awaiting FDA approval, but is currently being used to facilitate development of new chemotherapy drugs.  Read More

The nanobubbles are short-lived events that expand and burst, thus creating a small hole i...

U.S. researchers are developing a promising new approach to the targeting of individual cancer cells. The technique uses light-harvesting nanoparticles to convert laser energy into “plasmonic nanobubbles,” enabling drugs to be injected directly into the cancer cells through small holes created in the surface. Researchers claim that the delivery of chemotherapy drugs in this way is up to 30 times more effective on cancer cells than traditional drug treatments and requires less than one-tenth the clinical dose.  Read More

Gold nanostars like these are able to deliver drugs directly into the nucleus of cancer ce...

While effective at killing cancer cells, chemotherapy is currently a shotgun approach that can also harm healthy cells and cause serious side effects in patients. The ability to deliver drugs directly into cancer cells would provide a more targeted approach to more effectively treat the disease with lower doses of drugs and less side effects. Researchers at Northwestern University are claiming to be the first to develop gold nanostars that provide a much more precise approach by delivering a drug directly to a cancer cell’s nucleus.  Read More

The NovoTTF treatment involves placing pads onto the patient's skin that creates a low int...

The FDA (US Food and Drug Administration) has approved a new treatment for patients as an alternative to chemotherapy. The promising new non-invasive treatment by Novocure uses "Tumor Treating Fields" (NovoTTF) to treat cancerous growths and is now available for adult patients with recurring brain tumors (recurrent glioblastoma or GBM). The treatment delivers electric fields to a patient utilizing a portable, wearable device that permits the patient to maintain normal daily activities without down time.  Read More

Image of a mouse with implanted tumors before and after receiving photoimmunotherapy (PIT)...

Besides surgery, chemotherapy and radiation are the foundation of modern day cancer treatment. Although effective, these therapies often have debilitating and damaging side effects. But scientists at the National Cancer Institute in Bethesda, Maryland have been experimenting with a new form of therapy using infrared light to kill cancer cells and shrink tumors without damaging healthy tissue.  Read More

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