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Alzheimer's Disease

Although no one is announcing a cure for Alzheimer’s disease just yet, research recently conducted at the University of Southern California does at least offer a glimmer of hope. Using drugs known as TSPO (translocator protein) ligands, scientists there have successfully halted and even reversed the effects of Alzheimer’s in mice. Read More
What’s that mouse thinking about? Scientists at California’s Stanford University can now tell you – to a limited extent. They recently had success in imaging the neural activity of mice, in real time. While the ability to “read a mouse’s mind” may not fire many peoples’ imaginations, the technology could prove very useful in researching diseases like Alzheimer's. Read More

Scientists at VTT Technical Research Centre in Finland have developed new software called PredictAD that could significantly boost the early diagnosis of Alzheimer's disease. Read More

The process of deep brain stimulation involves using a pacemaker-like implanted device to apply controlled mild electrical pulses to specific areas of the brain. In recent studies, it has been used – with some success – to treat conditions such as Parkinson's disease, major depression and Tourette syndrome. Now, in the ADvance Study, researchers at several research centers are exploring its use in restoring memory function to people with Alzheimer’s disease. Read More
By turning off an immune system transmitter in mice with an Alzheimer’s-like condition, scientists have been able to greatly reduce the accumulation of an abnormal protein known as amyloid-ß in the animals’ brains. Previous studies have shown that the protein plays a central role in Alzheimer’s disease. It is hoped that the research may ultimately point the way towards a method of preventing or treating the disease in humans. Read More
Early diagnosis of Alzheimer’s disease can make a huge difference in the management of the disease, and this can be achieved by making testing procedures more easily accessible. For that reason, Georgia Institute of Technology researchers led by Ellen Yi-Luen Do have created a digital version of the Clock Drawing Test commonly used to detect cognitive impairment. The two-part evaluation does away with the paper and makes it easier for patients to get tested, besides giving doctors a more sophisticated tool for making assessments. Read More
As researchers look for better ways to diagnose Alzheimer’s disease in its early stages, one promising detection methodology to emerge is a simple eye tracking procedure developed by scientists at Lancaster University in conjunction with Royal Preston Hospital. The results of such tests can help flag initial signs of memory impairment that are associated with the onset of the disease. Read More

“Don’t make me angry. You wouldn’t like me when I’m angry,” the Hulk’s alter ego Bruce Banner famously said. Now researchers have made a discovery that might one day have implications for anyone considering Bruce as a potential house guest. The researchers have identified a brain receptor that malfunctions in overly hostile mice - a receptor that also exists in humans - and found a way to shut it down, offering the potential for the development of treatments for severe aggression. Read More

A new marker of Alzheimer’s disease can predict how rapidly a patient’s memory and other mental abilities will decline after the disorder is diagnosed, according to researchers at Washington University School of Medicine in St. Louis. Just released in Neurology were the results of a three-year long study that followed 60 patients with early Alzheimer's disease. The study found that rapid mental decline was predicted by the presence of larger levels of visinin-like protein 1 (VILIP-1) in the spinal fluid. Read More
We’ve reported on numerous different approaches by scientists looking to tackle Alzheimer’s disease. While some, such as the anticancer drug bexarotene and a compound known as J147, show great promise, there is still no approved treatment to slow the disease’s progression. The latest promising candidate for a treatment comes from Canada’s Simon Fraser University (SFU), where a team has concluded that ensuring that sugar levels in a brain protein known as tau are maintained could slow or prevent the fatal disease. Read More
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