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Alzheimer's Disease

Drugs called 'pharmacoperones' can fix the problems that occur when proteins 'misfold'

Proteins adopt their functional three-dimensional structure by the folding of a linear chain of amino acids. Gene mutation can cause this folding process to go awry, resulting in "misfolded" proteins that are inactive or, in worse cases, exhibit modified or toxic functionality. This is the cause of a wide range of diseases, but researchers have developed a technique that fixes these misfolded proteins, allowing them to perform their intended function, thereby providing a potential cure for a number of diseases.  Read More

According to researchers, a multi-photon laser technique can be used to detect protein agg...

It is generally believed that aggregations of proteins are responsible for brain disorders such as Alzheimer's, Parkinson's and Creutzfeldt-Jakob disease. However, the difficulty has been in detecting the aggregates responsible and removing them from the brain. Researchers at Chalmers University of Technology in Sweden and Polish Wroclaw University of Technology have found a potential solution using lasers.  Read More

Scientists have successfully used accelerometers to determine whether or not a person is s...

Among the behavioral symptoms of Alzheimer's, one of the most prominent is a change in the "temporal structure of activities" – in other words, the amount of time that it takes the patient to do things. With that in mind, German scientists have developed a new early detection method that involves attaching accelerometers to patients, in order to assess their movements.  Read More

New research has provided 'strong hope' of finding a drug to combat Alzheimer’s (Image: Sh...

A team of researchers at Yale University has completed a molecular model for Alzheimer's disease by identifying a protein that plays a key role in its onset. Promisingly, the study showed that when the activity of this protein is blocked by an existing drug, mice engineered as models for human AD recover their memories.  Read More

New hope could be on the way in the search for a treatment for Alzheimer's disease (Image:...

Although no one is announcing a cure for Alzheimer’s disease just yet, research recently conducted at the University of Southern California does at least offer a glimmer of hope. Using drugs known as TSPO (translocator protein) ligands, scientists there have successfully halted and even reversed the effects of Alzheimer’s in mice.  Read More

One of the test mice, and a live video feed of its fluorescing neurons

What’s that mouse thinking about? Scientists at California’s Stanford University can now tell you – to a limited extent. They recently had success in imaging the neural activity of mice, in real time. While the ability to “read a mouse’s mind” may not fire many peoples’ imaginations, the technology could prove very useful in researching diseases like Alzheimer's.  Read More

VTT researchers will spend the next five years carrying out the test at memory clinics in ...

Scientists at VTT Technical Research Centre in Finland have developed new software called PredictAD that could significantly boost the early diagnosis of Alzheimer's disease.  Read More

Scientists are looking into treating Alzheimer's disease by applying tiny shocks to the br...

The process of deep brain stimulation involves using a pacemaker-like implanted device to apply controlled mild electrical pulses to specific areas of the brain. In recent studies, it has been used – with some success – to treat conditions such as Parkinson's disease, major depression and Tourette syndrome. Now, in the ADvance Study, researchers at several research centers are exploring its use in restoring memory function to people with Alzheimer’s disease.  Read More

Plaque deposits in the brain tissue of an untreated mouse (left), and one treated in the s...

By turning off an immune system transmitter in mice with an Alzheimer’s-like condition, scientists have been able to greatly reduce the accumulation of an abnormal protein known as amyloid-ß in the animals’ brains. Previous studies have shown that the protein plays a central role in Alzheimer’s disease. It is hoped that the research may ultimately point the way towards a method of preventing or treating the disease in humans.  Read More

Reseachers at George Tech have created software that is a digital version of the Clock Dra...

Early diagnosis of Alzheimer’s disease can make a huge difference in the management of the disease, and this can be achieved by making testing procedures more easily accessible. For that reason, Georgia Institute of Technology researchers led by Ellen Yi-Luen Do have created a digital version of the Clock Drawing Test commonly used to detect cognitive impairment. The two-part evaluation does away with the paper and makes it easier for patients to get tested, besides giving doctors a more sophisticated tool for making assessments.  Read More

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