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Alzheimer's Disease

Scientists are looking into treating Alzheimer's disease by applying tiny shocks to the br...

The process of deep brain stimulation involves using a pacemaker-like implanted device to apply controlled mild electrical pulses to specific areas of the brain. In recent studies, it has been used – with some success – to treat conditions such as Parkinson's disease, major depression and Tourette syndrome. Now, in the ADvance Study, researchers at several research centers are exploring its use in restoring memory function to people with Alzheimer’s disease.  Read More

Plaque deposits in the brain tissue of an untreated mouse (left), and one treated in the s...

By turning off an immune system transmitter in mice with an Alzheimer’s-like condition, scientists have been able to greatly reduce the accumulation of an abnormal protein known as amyloid-ß in the animals’ brains. Previous studies have shown that the protein plays a central role in Alzheimer’s disease. It is hoped that the research may ultimately point the way towards a method of preventing or treating the disease in humans.  Read More

Reseachers at George Tech have created software that is a digital version of the Clock Dra...

Early diagnosis of Alzheimer’s disease can make a huge difference in the management of the disease, and this can be achieved by making testing procedures more easily accessible. For that reason, Georgia Institute of Technology researchers led by Ellen Yi-Luen Do have created a digital version of the Clock Drawing Test commonly used to detect cognitive impairment. The two-part evaluation does away with the paper and makes it easier for patients to get tested, besides giving doctors a more sophisticated tool for making assessments.  Read More

Researchers in the UK have found that an eye tracking measurement test can help detect ear...

As researchers look for better ways to diagnose Alzheimer’s disease in its early stages, one promising detection methodology to emerge is a simple eye tracking procedure developed by scientists at Lancaster University in conjunction with Royal Preston Hospital. The results of such tests can help flag initial signs of memory impairment that are associated with the onset of the disease.  Read More

Researchers have found to block pathological aggression in mice that could lead to new tre...

“Don’t make me angry. You wouldn’t like me when I’m angry,” the Hulk’s alter ego Bruce Banner famously said. Now researchers have made a discovery that might one day have implications for anyone considering Bruce as a potential house guest. The researchers have identified a brain receptor that malfunctions in overly hostile mice - a receptor that also exists in humans - and found a way to shut it down, offering the potential for the development of treatments for severe aggression.  Read More

A new marker of Alzheimer's disease can predict how rapidly a patient's memory and other m...

A new marker of Alzheimer’s disease can predict how rapidly a patient’s memory and other mental abilities will decline after the disorder is diagnosed, according to researchers at Washington University School of Medicine in St. Louis. Just released in Neurology were the results of a three-year long study that followed 60 patients with early Alzheimer's disease. The study found that rapid mental decline was predicted by the presence of larger levels of visinin-like protein 1 (VILIP-1) in the spinal fluid.  Read More

Maintaining sugar levels in a brain protein known as tau could slow or prevent Alzheimer's...

We’ve reported on numerous different approaches by scientists looking to tackle Alzheimer’s disease. While some, such as the anticancer drug bexarotene and a compound known as J147, show great promise, there is still no approved treatment to slow the disease’s progression. The latest promising candidate for a treatment comes from Canada’s Simon Fraser University (SFU), where a team has concluded that ensuring that sugar levels in a brain protein known as tau are maintained could slow or prevent the fatal disease.  Read More

An anticancer drug, bexarotene, reverses the physical and cognitive effects of Alzheimer's...

Studies of the anticancer drug bexarotene have shown that, in mice, the drug quickly reverses the physiological, cognitive, and memory deficits which are characteristic of Alzheimer's. More than half of the amyloid beta plaques associated with Alzheimer's were cleared from the brain within hours, and normal behavioral patterns which had been blocked by the plaques were restored within 72 hours.  Read More

A new compound, J147, could be the first drug capable of halting the progression of Alzhei...

Anyone who has watched as Alzheimer’s disease robs a friend or family member of their memories and faculties before ultimately claiming their life knows just what a truly horrible disease it is. According to the World Health Organization, it is the fourth leading cause of death in high-income countries and, due to an aging worldwide population, it is predicted to affect one in 85 people worldwide by 2050 – unless a treatment can be found. Scientists at the Salk Institute for Biological Studies have high hopes for a new drug they have developed that has improved memory and prevented brain damage in mice and is a promising candidate for the first drug capable of halting the progression of Alzheimer’s in humans.  Read More

The GPS Shoes allow real-time tracking of the wearer

As millions of baby boomers approach 65, the rates of Alzheimer’s sufferers is expected to continue to rise significantly in the coming decade. Already 5.4 million Americans are living with the disease with that figure predicted to rise to as many as 16 million by 2050, according to the Alzheimer’s Association. To make it easier for caregivers and family members to keep track of those suffering dementia, Personal Location Services company GTX Corp has partnered with comfort shoe manufacturer Aetrex to produce the GPS Shoe that allows real-time tracking of the wearer.  Read More

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