MIT engineers created vaccine-delivering nanoparticles by placing lipid spheres inside one another (Image: Peter DeMuth and James Moon)
Immune cells, tagged with green fluorescent protein, are surrounded by nanoparticles (red), after the nanoparticles are injected into the skin of a mouse (Image: Peter DeMuth and James Moon)
Vaccines work by exposing the body to an infectious agent in order to prime the immune system to respond quickly when it encounters the pathogen again. Some vaccines, such as the diphtheria vaccine, consist of a synthetic version of a protein or other molecule normally made by the pathogen, while others, such as the polio and smallpox vaccines, use a dead or disabled form of the virus. However, such an approach cannot be used with HIV because it's difficult to render the virus harmless. MIT engineers have now developed a new type of nanoparticle that could safely and effectively deliver vaccines for infectious diseases such as HIV and malaria, and could even help scientists develop vaccines against cancer.
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