Image of the induced neural stem cells created by reprogramming skin cells (Photo: MPI for Molecular Biomedicine)
Researchers at the Max Planck Institute for Molecular Biomedicine in Münster, Germany, have broken new ground by reprogramming skin cells from mice into neurons without regressing the cells through a pluripotent stage. The skin cells were reprogrammed directly into multipotent neuronal stem cells - that is, into cells which could only turn into new neurons. This procedure avoids the significant risk that pluripotent stem cells, which can grow into any type of tissue, may accidentally form tumors rather than the desired replacement tissue.
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