A nanoparticle delivery mechanism (left) treats tumors in mice more effectively
Tumor size in mice, left to right, with treatment with saline, just Dox, Gelipo-Dox, and Gelipo-TRAIL-Dox
A diagram of the process of Gelipo's targeted delivery of two different drugs to the cell membrane and nucleus
A common strategy for treating tumors is combining two or more drugs, which has the effect of decreasing toxicity and increasing the synergistic effects between the drugs. However, the efficacy of this kind of cocktail treatment suffers when the drugs require access to different parts of the cell, a bit like fighting a battle by depositing all your archers on the same spot as your infantrymen. By making use of nanoparticle-based carriers, researchers at North Carolina State University are able to transport multiple drugs into cancerous cells optimally and precisely, in maneuvers that any field commander would be proud of.
Other Images from this Gallery