Frequency map of MAGE-generated TAG::TAA codon replacements across the E. coli genome at each TAG codon replacement position. Frequency of TAG::TAA replacements by MAGE across all TAG codons denoted by height- and color-coded bars (Image: F.J. Isaacs et. al.)
Hierarchical conjugative assembly genome engineering (CAGE) was used to assemble codon changes into higher ordered strains of E. coli (Image: F.J. Isaacs et. al.)
DNA rendering by ynse via Flickr
While scientists have long had the ability to edit individual genes, it is a slow, expensive and hard to use process. Now researchers at Harvard and MIT have developed technologies, which they liken to the genetic equivalent of the find-and-replace function of a word processing program, that allow them to make large-scale edits to a cell’s genome. The researchers say such technology could be used to design cells that build proteins not found in nature, or engineer bacteria that are resistant to any type of viral infection.
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