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Hybrid 3D printer produces implantable cartilage

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November 23, 2012

The experimental 3D printer, which combines electrospinning and ink jet printing technolog...

The experimental 3D printer, which combines electrospinning and ink jet printing technologies

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Generally speaking, injured cartilage doesn’t heal well ... if at all. In recent years, however, scientists have successfully regrown cartilage at injury sites, using things like hydrogel, microspheres and collagen-based nano-scaffolding. Now, a team of scientists led by Prof. James Yu of North Carolina's Wake Forest Institute for Regenerative Medicine have developed something else – a 3D printer that creates implantable cartilage.

For some time now, it’s been possible to create items such as artificial arteries using what’s known as a 3D bio-printer. What’s unique about the new device is the technologies and printing materials that it combines.

One of those technologies is electrospinning. In this process, an electrical current is utilized to create fine fibers from a synthetic polymer solution. These fibers are used to create a porous nanostructure which serves as a sort of “nesting ground” for cartilage cells, making it easier for cartilage adjacent to the injury site to grow back into it.

Flexible mats of this electrospun polymer then have a solution of cartilage cells (obtained from a rabbit ear) deposited on them using traditional ink jet printing. A series of these “seeded” mats are layered together, until they form a structure measuring 10 cm (3.9 inches) diagonally by 4 mm thick.

A diagram of the cartilage-printing process

This material is the finished implantable cartilage. Due to its synthetic polymer content, it is said to offer considerably more mechanical stability than some previous efforts, which consisted of tissue made solely from ink jet-printed gel – an important consideration, given that the material would likely be implanted at high-stress areas such as knees.

Pieces of the 3D-printed cartilage were strength-tested with weights, plus they were implanted in mice. After eight weeks, the implanted samples reportedly “appeared to have developed the structures and properties that are typical of elastic cartilage, demonstrating their potential for insertion into a patient.”

A paper on the research was published yesterday in the journal Biofabrication.

Source: Institute of Physics

About the Author
Ben Coxworth An experienced freelance writer, videographer and television producer, Ben's interest in all forms of innovation is particularly fanatical when it comes to human-powered transportation, film-making gear, environmentally-friendly technologies and anything that's designed to go underwater. He lives in Edmonton, Alberta, where he spends a lot of time going over the handlebars of his mountain bike, hanging out in off-leash parks, and wishing the Pacific Ocean wasn't so far away.   All articles by Ben Coxworth
3 Comments

Can this sort of thing be done with Bone? For example, replacement of a broken collar bone with a nice new one so there was no lump left from old breaks. For some, these old injuries can be really frustrating as they change the geometry of the skeleton and therefore everything around needs to realign giving ongoing problems for decades.

Vaughan Barton-Johnson
25th November, 2012 @ 10:06 pm PST

I need two of these right now to avoid the barbaric process of knee replacement. I suppose availability for humans is many years away?

biscuitcutter
26th November, 2012 @ 03:56 pm PST

3D Printing is entering every technological strata and rapidly changing the industries for a better tomorrow. Use of 3D printing in medicine field is a live example of the potential it offers to the society.

david_benett
10th February, 2013 @ 09:04 pm PST
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