Dr. Antoni Ribas, associate professor of hematology-oncology and a researcher at UCLA's Jonsson Comprehensive Cancer Center
Bioluminescence imaging (BLI) of T cell trafficking in live mice used in the study
One of the main problems with cancer cells is that the body's immune system generally doesn’t recognize them as enemies. By using a crippled HIV-like virus as a vehicle to arm lymphocytes with T-cell receptors, researchers have been able to genetically engineer a well-armed battalion of tumor-seeking immune system cells. By also inserting a reporter gene, which glows “hot” during positron emission tomography (PET) scanning, the researchers were able to watch in real time as these "special forces" traveled throughout the body to locate and attack dangerous melanomas.
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