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Fusion molecule found to cure rheumatoid arthritis in mice

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August 6, 2014

A new fusion molecule, when combined with an anti-inflammatory drug, has been shown to cur...

A new fusion molecule, when combined with an anti-inflammatory drug, has been shown to cure rheumatoid arthritis in mice (Photo: Shutterstock)

While advances have been made in treating rheumatoid arthritis, an autoimmune disease causing inflammation of joints in the body, scientists are yet to develop a cure for the disease. But researchers from ETH Zurich, Switzerland have developed a new therapy that has shown to fully cure the condition in mice, leaving the team hopeful of commencing human trials as early as 2015.

The researchers developed a new type of molecule where an antibody is fused with the body's own immune messenger interleukin (IL-4). When injected, the antibody is drawn to a certain type of protein that only exists in inflamed tissue, taking the IL-4 component along for the ride. Previous studies have established that IL-4 is effective in preventing cartilage and bone damage in mice with rheumatoid arthritis, so merging the two meant that the researchers could target the disease with a new level of precision.

“As a result of combination with the antibody, IL-4 reaches the site of the disease when the fusion molecule is injected into the body,” says Teresa Hemmerle, pharmacist at ETH and lead author of the study. “It allows us to concentrate the active substance at the site of the disease. The concentration in the rest of the body is minimal, which reduces side-effects."

In testing the new molecule in mice with rheumatoid arthritis, the researchers observed its effects when combined with dexamethasone, an anti-inflammatory drug already used to treat the disease in humans. When administered on their own, both the fusion molecule and dexamethasone worked to slow the progress of the disease. However, when administered at the same time, symptoms such as swollen toes and paws disappeared within a few days.

“In our mouse model, this combined treatment creates a long-term cure,” says Hemmerle.

The scientists also observed the concentrations of various immune messengers in blood and inflamed tissue, which returned to normal levels following treatment with the fusion molecule. They are now preparing to test the drug in human trials, which they hope will begin within the next year.

The team's findings were published in the Proceedings of the National Academy of Science.

Source: ETH Zurich

About the Author
Nick Lavars Nick was born outside of Melbourne, Australia, with a general curiosity that has drawn him to some distant (and very cold) places. Somewhere between enduring a winter in the Canadian Rockies and trekking through Chilean Patagonia, he graduated from university and pursued a career in journalism. He now writes for Gizmag, excited by tech and all forms of innovation, Melbourne's bizarre weather and curried egg sandwiches.   All articles by Nick Lavars
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8 Comments

I have teached people with this disease and it really does make it impossible to find a job that will cater to such needs, hope this is a success.

JSmith
7th August, 2014 @ 01:13 am PDT

JSmith, don't know what the heck you just posted but if you suffer from RA I feel your pain. Where do I sign up for the human trials?

Minerfanatic
7th August, 2014 @ 08:44 am PDT

PLEASE sign me up for the trials , I have had RA for 10 yrs .

Lee Bouvier
7th August, 2014 @ 09:51 am PDT

Jsmith, you "teached" students with RA?? Though the disease can limit a person's mobility and ability to perform daily tasks, there are RA drugs currently available to slow down the disease progression. I can't wait until human trials begin.

Linsch
7th August, 2014 @ 10:24 am PDT

Please add me as well to the Trail list if there is any way to do so, I have been suffering for the last four years, no one can imagine what I have been through.. but all I have is HOPE!

Firas Alwakeel

fwakeel
7th August, 2014 @ 11:11 am PDT

Sounds promising. Brilliant!

Grunchy
7th August, 2014 @ 09:51 pm PDT

I.ve had RA for 36 yrs .I have joint damage mainly to my hands .

That treatments look very promising for those who are new to the disease where there is no damage yet .I hope it is successful treatment and works on everyone .

Eileen Conrod
16th August, 2014 @ 05:03 am PDT

Where do they find these mice with rheumatoid arthritis? Do they mess with the mouse's immune system until it turns on itself?

Jen Torrey
28th August, 2014 @ 06:12 pm PDT
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