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Maybe free radicals aren't so bad after all - at least for worms

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February 10, 2011

A new study raises questions about one of the favored theories of aging involving increasi...

A new study raises questions about one of the favored theories of aging involving increasing production of free radicals (Photo: Noel McKeegan / Gizmag)

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A recent study suggests that, at least for worms, free radicals may not be the "bad guys" after all. It turns out that if you are a bacteria-eating worm of the species C. elegans, genetic modifications that raise your free radical levels don't have the negative effect expected, but instead serve to lengthen lifespan. The effect was negated by exposure to known antioxidants such as vitamin C. C. elegans also seems to thrive when exposed to the herbicide Paraquat which is known to dramatically increase free radical levels in animals, so much so that it has been banned in the EU and its use is restricted in most other countries. C. elegans actually lived longer when exposed to Paraquat. It remains unclear what, if any, significance this has for humans so don’t stop eating your antioxidant-rich fruits and veggies just yet.

Free radicals are molecules that are produced by our bodies as it processes oxygen. Many mammalian cell functions consume oxygen, generating free radicals as a by-product, which in turn causes damage to those same cells. This is called “oxidative stress” and has been broadly understood to be a degradative process in cells. This is one of the key reasons antioxidants have become a buzz word in both conventional and complementary medicine in recent years. One of the favored theories of aging suggests that the process is caused by a endless downward spiral involving increasing production of free radicals, leading to cellular damage and a consequent increase in free radicals as a result of that damage. Consuming dietary antioxidants, in food or as supplements, can reverse this spiral.

If you are a bacteria-eating worm of the species C. elegans, genetic modifications that ra...

“These findings challenge our understanding of how free radicals are involved in the aging process,” said Dr. Siegfried Hekimi a researcher at McGill’s Department of Biology responsible for the C. elegans study. “The current theory is very neat and logical, but these findings suggest a different framework for why oxidative stress is associated with ageing. Further experimentation is required to explore exactly how this data might change our theory of ageing. Free radicals are clearly involved, but maybe in a very different way than in the way people used to think.”

Theories of Aging

It is apparent that aging is a complex process that we are yet to fully understand. We have looked previously at the “Calorie Restriction Theory” and the “Telomere Theory” and some new technologies to potentially lengthen lifespan via specific telomerase enzyme inhibitors. Calorie Restriction, the Telomere Theory and the Free Radical Theory are just three of 15 distinct but somewhat overlapping concepts of why we age and until researchers settle on a integrated view – and more importantly, exactly what we can all do about it – the fountain of youth seems to still be out of reach.

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