SHELTER device traps and removes blood clots in the brain Credit: Zina Deretsky, NSF
The Insera SHELTER device is minuscule so that it can fit into even tiny blood vessels in the brain. The framework holding open the clot-capturing mesh compresses down to fit within a catheter, only opening when it is pushed past the blood clot, when the heat of the body causes the memory metal device to spring into this shape. Credit: Insera Therapeutics
During testing, the SHELTER device grabs a simulated blood clot (a moistened gummi bear) from within a silicone "blood vessel." The water-filled, silicone test-bed was modeled from human-cadaver brain vessels, and contains added aneurysms, atherosclerosis and "plaque" to provide the device an even more challenging testing environment. The new test-bed is more accurate than certain animal tests, and has helped speed the device's development. Potentially, the test-bed could present a new approach to late-stage evaluation of certain medical technologies. Credit: Insera Therapeutics
By using silicone copies of human cadaver blood vessels--further modified with aneurisms, atherosclerosis and "plaque"--Insera researchers are able to recreate a model environment for testing their blood-clot removal device. The cadaver model approach could potentially replace some animal testing experiments. Credit: Insera Therapeutics
By the time you finish reading this, two people in the U.S. will have suffered a stroke, or brain attack. Strokes are the third leading cause of death in the United States and claimed over 130,000 lives last year. Of those who survive, hundreds are left debilitated every day. Ischemic strokes, a blood clot or break in blood vessels in the brain, are responsible for 80% of all strokes. Fast treatment is critical; more than a million brain cells die each minute after onset of a symptoms, and the risk of brain damage increases rapidly if the clot is not removed within three hours. A new device, SHELTER, offers hope of extending the time a patient can get help. It filters and removes clots and can be custom-fit for the specific length and diameter of a patient's clot.
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