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Crab shells used to produce cheaper pharmaceuticals

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February 14, 2012

The chitin found in crab and lobster shells is being used in a process that could lead to ...

The chitin found in crab and lobster shells is being used in a process that could lead to much cheaper antiviral drugs

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Crabs and lobsters ... they're not just for eating, anymore. Chitin, one of the main components of their exoskeletons, has recently found use in things such as self-healing car paint, biologically-compatible transistors, flu virus filters, and a possible replacement for plastic. Now, something else can be added to that list. Researchers from the Vienna University of Technology are developing a technique in which chitin is being used to cheaply produce a currently very-expensive source of antiviral drugs.

Many presently-used antiviral drugs are derived from N-Acetylneuraminic acid, also known as NANA. The substance can synthesized or obtained from natural sources, but in either case it is very costly - at about 2,000 euro (US$2,626) a gram, it is approximately 50 times more valuable than gold.

To produce cheaper NANA, the Vienna scientists introduced bacterial genes into a very common fungus called Trichoderma. Normally, the fungus feeds on chitin and breaks it down into monomer amino sugars. With the addition of the new genes, however, a couple of extra steps are added to the process, with the chitin ending up as - you guessed it - N-Acetylneuraminic acid.

Some of the bioreactors being used to cultivate the bioengineered Trichoderma fungus

The bioengineered Trichoderma can be cultivated in bioreactors, and finding enough food for it shouldn't be a problem ... chitin is the second-most common biopolymer on earth, occurring not only in crab and lobster shells, but also in insect exoskeletons, snail shells, cephalopods (such as squid), and some fungi.

The reportedly eco-friendly process has been patented, and the researchers hope to see industrial-level production of cheap NANA beginning soon.

Source: Vienna University of Technology

About the Author
Ben Coxworth An experienced freelance writer, videographer and television producer, Ben's interest in all forms of innovation is particularly fanatical when it comes to human-powered transportation, film-making gear, environmentally-friendly technologies and anything that's designed to go underwater. He lives in Edmonton, Alberta, where he spends a lot of time going over the handlebars of his mountain bike, hanging out in off-leash parks, and wishing the Pacific Ocean wasn't so far away.   All articles by Ben Coxworth
2 Comments

As a commercial lobster fisherman for over 20 years, I can testify to the fact that when un-intentionally poked by a lobster or crab shell (and some fish), a person has a better chance of going through the year without getting sick.

Richard Dicky Riddlebarger
15th February, 2012 @ 09:08 am PST

I'm allergic to shellfish. How would this medicine affect people like me?

valerie
15th February, 2012 @ 06:03 pm PST
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