Image of nuclei of proliferating neural stem cells (green) and blood vessels (red) tunneling into a mouse's transparent hippocampus
A three-dimensional reconstruction of neurons expressing yellow fluorescent protein in a mouse's cerebral cortex and hippocampus, obtained using Scale
The clear mouse embryo on the right was incubated in the Scale reagent for two weeks
Scientists are constantly looking for new and better ways of seeing through biological tissue, in order to see cells within it that have been marked with dyes, proteins or other substances. While recent research has involved using marking materials such as carbon nanotubes and firefly protein, scientists from Japan’s RIKEN Brain Science Institute have taken a different approach – they’ve developed a chemical reagent that causes the tissue surrounding the marked cells to become transparent.
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